基于兔NAFLD模型的双源CT及MRI肝脏脂肪定量研究

发布时间：2018-03-07 15:44

本文选题：脂肪肝　切入点：肝脏脂肪含量　出处：《放射学实践》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨双源CT及MRI对肝脏脂肪含量测量的准确性。方法:50只雄性新西兰家兔随机分为两组,A组42只(实验组),氋脂饲料喂养;B组8只(对照组),普通饲料喂养,共喂养16周。在开始喂养后的不同时期进行双源CT、MRI三维同相位和反相位及最小二程估算法迭代水脂分离(IDEAL-IQ)序列扫描。测量不同单能量图像上肝脏的CT值、MRI同相位和反相位序列的肝脏脂肪含量(HFF)、IDEAL-IQ序列的质子密度脂肪分量(PDFF)。后经酸水解法获得新鲜肝脏的脂肪含量。将单能量图像上肝脏的CT值、HFF、PDFF与病理结果进行Spearman相关性分析。结果:对照组正常肝脏及实验组轻、中、重度脂肪肝的CT值、PDFF及HFF值差异均有统计学意义(P0.05)。CT值与病理结果呈负相关,PDFF、HFF与病理结果呈正相关(P0.05)。双源CT扫描80keV CT值与病理结果的相关性最好(r=-0.870);PDFF与病理结果的相关性(r=0.936)高于HFF(r=0.853)。结论:IDEAL-IQ序列所测的肝脂肪含量与肝实际脂肪含量的相关性高于同相位和反相位序列及双源CT。
[Abstract]:Objective: to investigate the accuracy of dual-source CT and MRI in the measurement of hepatic fat content. Methods: fifty male New Zealand rabbits were randomly divided into two groups: group A (n = 42), group B (n = 8) fed with fat diet (control group, n = 8). A total of 16 weeks of feeding were performed. Three-dimensional in phase and inverse phase and least square estimation method were used to iterate the IDEAL-IQ sequence scanning of the liver at different stages after feeding. Ct values of liver on different single energy images were measured and MRI was in phase. The fat content of the fresh liver was obtained by acid hydrolysis method. The correlation between the CT value of the liver and pathological results was analyzed by Spearman. Results: the normal liver of the control group and the experimental group were mild, The difference of CT value and HFF value in severe fatty liver is statistically significant. There is a negative correlation between the CT value and pathological results. There is a positive correlation between HFF and pathological results. The correlation between CT value of 80 Kev and pathological results is the best. The correlation between PDFF and pathological results is the best. Conclusion the correlation between the liver fat content and the actual fat content in the liver measured by the WIDEAL-IQ sequence is higher than that in the same phase and inverse phase sequence and dual source CTs.
【作者单位】：首都医科大学附属北京友谊医院放射科;广西医科大学附属第一医院放射科;
【分类号】：R445.2;R575.5;R816.5

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