超声电导经皮透入微米活血镇痛散治疗兔急性软组织损伤的实验研究

发布时间：2018-03-08 23:32

本文选题：超声电导　切入点：微米活血镇痛散　出处：《时珍国医国药》2015年03期 　论文类型：期刊论文

【摘要】：目的观察超声电导经皮透入微米活血镇痛散对兔急性软组织损伤的治疗作用,探讨其促进损伤组织修复的作用机理。方法用自制打击器,造成兔后肢大腿外侧,距窝4~7cm处软组织挫伤的模型,造模成功后随机分4组,即模型组(1组)、超声电导物理治疗组(2组)、超声电导经皮透入微米活血镇痛散组(3组)及微米活血镇痛散外敷组(4组)。于造模2h后开始治疗(1组除外),连续4d。以软组织挫伤处肿胀面积、外周血液白细胞数变化、光镜下组织学变化为观察指标。结果四组间观察指标差异均具有统计学意义(P0.01)。其中2组、3组及4组于第2、3、4天肿胀面积减轻程度均优于1组(P0.01);与造模前比较,造模后四组外周血液白细胞数目均明显升高(P0.01),与1组比较,3组、4组均能明显减少损伤局部白细胞数(P0.01);治疗4d后病理组织学观察评分,3组、4组较1组能明显减轻炎症反应,促进损伤局部胶原纤维合成,肌纤维组织修复(P0.01)。各指标观察统计发现第3组改善较第2、4组改善最明显(P0.01)。结论超声电导经皮透入微米活血镇痛散治疗兔急性软组织损伤具有较好的消肿抗炎,减轻炎症反应,促进炎性渗出物吸收及损伤处软组织修复作用。作用明显优于超声电导物理治疗及微米活血镇痛散外敷。
[Abstract]:Objective to observe the therapeutic effect of transdermal ultrasonic conductance through micron blood activating analgesia powder on acute soft tissue injury in rabbits and to explore the mechanism of promoting the repair of the injured tissue. Methods A self-made instrument was used to induce the lateral side of the hindlimb thigh of the rabbit. The model of soft tissue contusion at the distance of 4 to 7 cm from the fossa was randomly divided into 4 groups after the successful establishment of the model. That is, model group 1, ultrasonic conductance physical therapy group 2, ultrasonic conductance transdermal penetration of micron blood activating analgesic powder group 3) and micron activating blood circulation analgesic powder external application group 4, except group 1 after 2 hours of model making, continuous 4 days. Swelling area of soft tissue contusion, Changes in the number of white blood cells in peripheral blood, Results the difference of the observed indexes among the four groups was statistically significant (P 0.01). The extent of the swelling area in group 2 and group 4 was better than that in group 1 on the 3rd day of the second day, compared with that in group 1. The number of white blood cells in peripheral blood fluid of the four groups increased significantly after the establishment of the model, compared with the first group, the white blood cell count of the injured local leukocytes was significantly reduced in all the 4 groups, and the histopathological score was observed 4 days after the treatment, and the inflammatory reaction was significantly alleviated in the 3 groups than in the first group. Promote the synthesis of injured local collagen fibers, The results showed that the improvement of group 3 was more obvious than that of group 2 (4). Conclusion Ultrasonic conductance transcutaneous penetration of micronutrient Huoxue analgesia powder in treating acute soft tissue injury in rabbits has a good effect on reducing swelling and inflammation and lightening inflammatory reaction. The effect of promoting the absorption of inflammatory exudates and repairing the soft tissue in the injured area was obviously superior to that of ultrasonic conductance physical therapy and micron Huoxue analgesic powder external application.
【作者单位】：广州医科大学附属第二医院;南方医科大学珠江医院;
【基金】：广东省科技计划项目(No.2007B35802005)
【分类号】：R445.1;R285.5

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