导管室内平板探测器CT定量评估兔肝肿瘤血管生成研究

发布时间：2018-03-13 02:08

本文选题：平板探测器　切入点：计算机断层摄影　出处：《介入放射学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨导管室内平板探测器CT(FDCT)技术定量评估肝肿瘤血管生成的可行性。方法25只新西兰大白兔VX2肝肿瘤模型构建后行FDCT检查,重建肿瘤血容量(BV)灌注图,分别检测肝肿瘤和肝实质BV值。FDCT检查后处死所有实验兔,取相应部位肝肿瘤标本检测微血管密度(MVD)和血管内皮细胞生长因子(VEGF)表达,分析肝肿瘤BV值与MVD和VEGF表达的关系。结果 25只实验兔中22只兔(88%)成功完成FDCT检查,BV灌注图均清晰显示肝组织和肿瘤,肝肿瘤表现为高灌注环伴低灌注中心的环状强化模式。肿瘤BV值与MVD和VEGF分级均存在良好相关性(P值均0.05),MVD与VEGF分级呈正相关(r=0.504,P0.001)。结论导管室内FDCT检查可定量评估肝肿瘤血管生成情况,可能有助于肝肿瘤介入诊疗。
[Abstract]:Objective to investigate the feasibility of intraductal flat panel detector (CTFDCT) technique for quantitative evaluation of angiogenesis in hepatic tumors. Methods 25 New Zealand white rabbits with VX2 liver tumor models were examined by FDCT to reconstruct the tumor blood volume (BV) perfusion. The BV value of liver tumor and liver parenchyma were detected. All the experimental rabbits were killed by FDCT. The microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) were detected in the corresponding liver tumor specimens. The relationship between BV value and MVD and VEGF expression in liver tumor was analyzed. Results 22 out of 25 experimental rabbits completed FDCT examination successfully and BV perfusion graph showed liver tissue and tumor clearly. Liver tumors showed a circular enhancement pattern with high perfusion ring and low perfusion center. There was a good correlation between BV value and MVD and VEGF grade. There was a positive correlation between BV value and VEGF grade (P 0.001). Conclusion FDCT examination can be used to quantitatively evaluate liver. Tumor angiogenesis, It may be helpful to the interventional diagnosis and treatment of liver tumor.
【作者单位】：上海交通大学医学院附属仁济医院放射科;
【基金】：国家自然科学基金(81201172) 上海交通大学医工交叉研究基金(YG2013MS37)
【分类号】：R730.44;R735.7

【相似文献】