3.0T MRI水通道蛋白分子成像在胰腺癌的应用价值

发布时间：2018-03-13 02:37

本文选题：胰腺肿瘤　切入点：水通道蛋白　出处：《放射学实践》2017年11期 　论文类型：期刊论文

【摘要】：目的:探讨3.0T MRI水通道蛋白分子成像定量参数(ADC_(AQPs))在胰腺癌的应用价值。方法:采用GE Discovery MR750 3.0T磁共振扫描仪对临床或手术病理证实的37例胰腺癌患者行胰腺多b值DWI。应用水通道蛋白AQPs模型、非高斯IVIM双指数模型和拉伸指数模型分析多b值DWI,测量胰腺癌和非癌胰腺组织的水通道蛋白扩散系数(ADC_(AQPs))、纯扩散系数(ADC_(slow))和分布扩散系数(DDC),采用独立样本t检验进行统计学分析。结果:胰腺癌的ADC_(AQPs)值和ADC_(slow)值明显高于非癌胰腺组织(0.346vs.0.202μm~2/ms,P0.001;0.611vs 0.521×10~(-3) mm~2/s,P=0.037),胰腺癌的DDC值明显低于非癌胰腺组织(1.244vs 1.679×10~(-3) mm~2/s,P=0.013),差异均有统计学意义。与ADC_(slow)和DDC相比,ADC_(AQPs)鉴别胰腺癌和非癌胰腺组织时的诊断效能更高(0.8900.6990.640)。胰腺癌的ADC_(AQPs)值和ADC_(slow)值呈正相关(r=0.414,P=0.015)。结论:水通道蛋白扩散系数ADC_(AQPs)和非高斯模型DWI扩散系数(ADC_(slow)、DDC)可以有效鉴别胰腺癌和非癌胰腺组织,ADC_(AQPs)是鉴别胰腺癌和非癌胰腺组织的最佳参数,3.0T MRI水通道蛋白分子成像是无创性早期诊断和鉴别胰腺癌与非癌胰腺组织的理想方法之一。
[Abstract]:Objective: to evaluate the value of 3.0T MRI aquaporin molecular imaging quantitative parameters in pancreatic cancer. Methods: using GE Discovery MR750 3.0T MRI scanner, 37 patients with clinically or surgically proved pancreatic carcinoma were treated with multi-b value of pancreas. DWI. using aquaporin AQPs model, Non-#china_person0# IVIM double index model and stretching index model were used to analyze multi-b DWI. The diffusion coefficient of aquaporin in pancreatic cancer and non-cancerous pancreatic tissue was measured, the pure diffusion coefficient and distribution diffusion coefficient were measured by independent sample t test. Results: the DDC value of pancreatic cancer was significantly higher than that of non-cancerous pancreatic tissue (0.346vs.0.202 渭 m P0.0010.611 vs 0.521 脳 10 ~ (-3)). The DDC value of pancreatic cancer was significantly lower than that of non-cancerous pancreatic tissue (1.244 vs 1.679 脳 10 ~ (-3) mm) P _ (0.013). The diagnostic efficacy of adenocarcinoma and non-cancerous pancreatic tissues was higher than that of non-cancerous pancreatic tissues (0.8900.6990.640). There was a positive correlation between the value of ADCStat AQPs and the value of ADCSP-D _ (slow) in pancreatic cancer. Conclusion: the aquaporin diffusion coefficient (ADCS) and the non-#china_person0# model (DWI) can be used to differentiate pancreatic cancer from non-cancerous pancreatic carcinoma. MRI aquaporin molecular imaging is the best parameter for differentiating pancreatic cancer from non-cancerous pancreatic tissues. It is one of the ideal methods for early diagnosis and differential diagnosis of pancreatic cancer and non-cancerous pancreatic tissues.
【作者单位】：第四军医大学西京医院放射科;
【基金】：国家自然科学基金重大国际(地区)合作与交流项目(81220108011);国家自然科学基金青年面上连续项目(81370039)
【分类号】：R445.2;R735.9

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