基于静息态fMRI的难治性癫痫患者丘脑功能连接研究

发布时间：2018-03-16 04:24

本文选题：癫痫　切入点：功能磁共振成像　出处：《安徽医科大学学报》2015年06期 　论文类型：期刊论文

【摘要】：目的利用静息态功能磁共振成像(f MRI)中的功能连接方法,探讨难治性癫痫患者丘脑的功能连接改变及意义。方法难治性癫痫患者19例,多模态神经影像学检查中颅内均未发现明显致痫病灶,发作间期及发作期长程视频脑电图提示双侧大脑半球棘波及棘慢波;同期招募19例健康对照者。采集静息态f MRI数据,分别以左、右丘脑为感兴趣区(ROI)与全脑进行功能连接分析,了解难治性癫痫患者相对于正常对照组功能连接增高和减弱的区域。结果以左侧丘脑为ROI做功能连接分析,难治性癫痫组与双侧梭状回、右侧舌叶、双侧楔叶及双侧楔前叶的功能连接强度增强,而与双侧尾状核、左侧壳核及左侧杏仁核的功能连接强度减弱;以右侧丘脑为ROI做功能连接分析,难治性癫痫组与双侧距状回、双侧楔前叶及左侧直回的功能连接强度增强,而与双侧壳核、双侧尾状核、双侧杏仁核及右侧脑岛的功能连接强度减弱。结论难治性癫痫患者静息状态下丘脑功能连接异常,丘脑可能参与了"癫痫网络"的构成。
[Abstract]:Objective to investigate the changes and significance of functional junctions in thalamus of patients with refractory epilepsy by using the functional junction method in resting functional magnetic resonance imaging (MRI). Methods 19 patients with refractory epilepsy were included in this study. In the multimodal neuroimaging examination, there were no obvious epileptic lesions in the brain. The interictal and long-term video EEG showed bilateral cerebral hemispheres spines and spines slow waves, and 19 healthy controls were recruited at the same time. The resting f MRI data were collected. Using left and right thalamus as region of interest (ROI) and the whole brain, respectively, the functional junctions of the patients with intractable epilepsy were analyzed. Results the left thalamus was used as the ROI to analyze the functional junctions in the patients with refractory epilepsy compared with the control group. In the intractable epilepsy group, the functional connective strength of bilateral fusiform gyrus, right lingual lobe, bilateral cuneiform lobe and bilateral precuneiform lobe was enhanced, while that with bilateral caudate nucleus, left putamen nucleus and left amygdala decreased. The right thalamus was used as ROI to analyze the functional junctions. In the intractable epilepsy group, the strength of the functional junctions between the bilateral talar gyrus, bilateral anterior cuneate lobe and left straight gyrus was enhanced, but with the bilateral putamen nucleus and the bilateral caudate nucleus. Conclusion the hypothalamus functional junction is abnormal in patients with refractory epilepsy, and the thalamus may be involved in the formation of "epileptic network".
【作者单位】：安徽医科大学附属省立医院影像科;安徽医科大学附属省立医院神经外科;
【基金】：安徽省自然科学基金(编号:11040606M167) 安徽省科技攻关计划项目(编号:1301042201)
【分类号】：R742.1;R445.2

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