不同性别海洛因依赖者低频振幅的差异

发布时间：2018-03-17 06:47

本文选题：海洛因依赖　切入点：性别差异　出处：《中国医学计算机成像杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的:在静息状态下,观察不同性别海洛因依赖者默认模式网络(DMN)低频振幅的变化。方法:被试者包含26名海洛因依赖者(HD组)和20名健康对照者(HC组)。其中,HD组来自复旦大学附属华山医院心理咨询门诊、上海交通大学医学院附属瑞金医院临床心理科门诊和上海交通大学医学院附属上海市精神卫生中心,男性14名,女性12名。HC组来自复旦大学附属华山医院体检中心。所有被试者完成一般人口学和成瘾相关资料后,进行功能磁共振扫描获取静息态磁共振数据。一般人口学及成瘾相关资料采用SPSS 16.0软件进行统计学分析,fMRI数据使用SPM8软件分析。结果:HD组和HC组被试者均完成一般人口学和成瘾相关资料的评估。因为明显头动,HD组2例和HC组1例磁共振数据被剔除。两组被试者的年龄、受教育年限及性别构成比差异均未见统计学意义(P0.05)。静息态低频振幅的结果显示,与HC组相比,HD组患者的左侧扣带回后部、右侧中央旁小叶、双侧额上回内侧、双侧颞中回及右侧楔前叶的低频振幅活动明显减弱。与女性相比,男性HD患者的缘上回、角回及额上回内侧脑区的低频振幅活动增强;但右侧楔前叶、左侧颞上回、左侧颞中回和左侧中央旁小叶的ALFF活动则减弱。结论:海洛因依赖改变了大脑DMN的功能,这种变化存在着性别差异。
[Abstract]:Objective: in a resting state, The changes of low frequency amplitude of DMN in heroin addicts with different genders were observed. Methods: the subjects included 26 heroin addicts with HD) and 20 healthy controls with HC group. The HD group was from Hua Hua affiliated to Fudan University. Psychological consultation Clinic of Shan Hospital, Shanghai Mental Health Center, affiliated to Shanghai Jiaotong University Medical College, 14 males, Department of Clinical Cardiology, Ruijin Hospital affiliated to Shanghai Jiaotong University Medical College, Shanghai Jiaotong University Medical College, Twelve female. HC group were from the medical examination center of Huashan Hospital affiliated to Fudan University. After all the subjects completed the data of general demography and addiction, The rest magnetic resonance data were obtained by functional magnetic resonance scanning. The data of general demography and addiction were analyzed by SPSS 16.0 software. The data of fMRI were analyzed by SPM8 software. Assessment of demographic and addiction-related data. Magnetic resonance data were removed from 2 patients in HD group and 1 in HC group. Age of the subjects in both groups. There was no significant difference in length of education and sex composition ratio. The results of low frequency amplitude of resting state showed that the left cingulate gyrus posterior part, right central paralobular lobules, bilateral superior frontal gyrus medial, left cingulate gyrus, bilateral superior frontal gyrus, and left cingulate gyrus in HD group compared with HC group. The low frequency amplitude activity of bilateral middle temporal gyrus and right anterior cuneate lobe was significantly decreased. Compared with female HD patients, the low frequency amplitude activity in superior marginal gyrus, angular gyrus and medial area of superior frontal gyrus was increased in male patients, but in right anterior cuneate lobe, left superior temporal gyrus. The activity of ALFF in the left middle temporal gyrus and the left paracentral lobules was decreased. Conclusion: heroin dependence changes the function of DMN in the brain and there is a gender difference in this change.
【作者单位】：复旦大学附属华山医院精神医学科;上海交通大学医学院附属上海市精神卫生中心;上海交通大学医学院附属瑞金医院临床心理科;
【基金】：上海市卫生局课题No.20114358 国家自然科学基金青年基金No.81201033 复旦大学人才培养项目No.JJF151057~~
【分类号】：R445.2;R749.64

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