声触诊组织量化技术无创评价慢性肝病的初步研究

发布时间：2018-03-17 13:18

本文选题：声触诊组织量化技术　切入点：声脉冲辐射力成像　出处：《临床超声医学杂志》2012年10期 　论文类型：期刊论文

【摘要】：目的探讨声触诊组织量化(VTQ)技术无创评价肝纤维化程度的临床应用价值。方法 62例肝纤维化患者(S1~S3期组)、36例肝硬化患者(S4期组)及50例健康志愿者(对照组),应用VTQ技术定量检测肝实质剪切波速度。结果对照组、S1~S3期组及S4期组患者剪切波速度分别为(1.11±0.19)m/s、(1.62±0.41)m/s及(2.48±0.53)m/s,三者比较差异有统计学意义(P㩳0.05)。S1~S3期组ROC曲线下面积为0.801,S4期组ROC曲线下面积为0.956。剪切波速度以1.30m/s为界值,诊断S1~S3期的敏感性为81%,特异性为79%;以1.81m/s为界值,诊断S4期的敏感性为92%,特异性为85%。结论 VTQ可无创测量肝实质剪切波速度,客观反映肝组织的弹性模量,有望为定量评估肝纤维化和肝硬化提供一种客观、准确的新方法。
[Abstract]:Objective to investigate the clinical application value of acoustic palpation tissue quantification (VTQs) technique in noninvasive assessment of hepatic fibrosis. Methods Sixty-two patients with hepatic fibrosis were treated with S1S3 phase group and 36 patients with cirrhosis with S4 stage) and 50 healthy volunteers (control group). Results the shear wave velocities were 1.11 卤0.19 m / s and 2.48 卤0.53 m / s in the control group and S4 group, respectively. There was a significant difference among the three groups (P < 0.05). The shear wave velocities of liver parenchyma were measured by VTQ technique, and the results showed that the shear wave velocities in the control group were 1.11 卤0.19 m / s and 2.48 卤0.53 m / s, respectively, and there were significant differences among the three groups (P < 0.05). The area under the ROC curve of stage 0.801and S4 was 0.956. The sensitivity of diagnosing S1 / S3 was 81m / s, the specificity was 79g / s, the value of shear wave velocity was 1.30m / s, and the value of 1.81m / s was taken as the boundary value, and the area under the ROC curve was 0.801m / s and 0.801m / s respectively, and the sensitivity of S1S3 was 81m / s, and the specificity was 79g / s. Conclusion VTQ can measure the shear wave velocity of hepatic parenchyma and objectively reflect the elastic modulus of liver tissue. It is expected to provide an objective and accurate new method for quantitative evaluation of liver fibrosis and cirrhosis.
【作者单位】：兰州军区乌鲁木齐总医院超声科;兰州军区总医院超声科;
【分类号】：R575.2

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