早期帕金森病患者脑白质损害的扩散张量成像研究

发布时间：2018-03-18 04:27

  本文选题：帕金森病　切入点：磁共振成像　出处：《放射学实践》2017年12期 　论文类型：期刊论文

【摘要】：目的:采用基于纤维束示踪的空间统计方法分析(TBSS)早期帕金森病患者扩散张量成像(DTI)数据,研究早期帕金森病患者脑白质结构损害情况及与运动症状的相关性。方法:18例早期帕金森病(PD)患者(Hoehn-Yahr 1~2级)及22例健康志愿者(对照组)行DTI扫描,采用TBSS技术对两组受试者的DTI数据进行分析,比较两组受试者脑白质纤维的部分各向异性(FA)值的差异,及其与帕金森病评估量表(UPDRS-Ⅲ)评分的相关性,测量并比较先发病侧与对侧大脑白质的FA值。结果:全脑分析显示:与正常对照组相比,PD组双侧额顶部、放射冠、胼胝体和扣带回的脑白质FA值明显减低(P0.05),且其范围均与UPDRS-Ⅲ评分呈负相关(r=-0.479~-0.736,P0.05);早期PD患者先发病侧大脑与对侧大脑比较,后放射冠、顶叶及颞叶的脑白质FA值的差异有统计学意义(P0.05)。结论:早期PD患者即可见脑白质纤维结构的改变,大脑白质损害程度与PD患者运动症状有密切联系,PD患者脑白质损害的部位可能存在一定的顺序。
[Abstract]:Objective: to analyze the DTI data of early Parkinson's disease patients with TBSS using spatial statistical method based on fiber tracer. To study the changes of white matter structure in patients with early Parkinson's disease and their correlation with motor symptoms. Methods DTI scans were performed in 18 patients with early Parkinson's disease (PDD) and 22 healthy volunteers (control group) with Hoehn-Yahr grade 1 / 2. The TBSS technique was used to analyze the DTI data of the two groups. The difference of partial anisotropy of white matter fibers between the two groups was compared, and the correlation between the values and the PD RS- 鈪，

本文编号：1628005