彩色多普勒超声评价脐血干细胞移植治疗失代偿期肝硬化效果的价值

发布时间：2018-03-19 10:10

本文选题：脐血干细胞　切入点：移植　出处：《广东医学》2015年18期 　论文类型：期刊论文

【摘要】：目的探讨彩色多普勒超声评价经脐血干细胞移植治疗失代偿期肝硬化效果的价值。方法选取100例失代偿期肝硬化患者,根据其意愿分为常规治疗组与干细胞治疗组各50例,常规治疗组给予常规保肝治疗,干细胞治疗组在此基础上给予脐血干细胞移植治疗。所有患者在治疗前后空腹检测肝功能与血脂功能,并进行彩色多普勒超声监测血流情况,同时评价临床疗效。结果治疗后两组谷丙转氨酶、谷草转氨酶、三酰甘油、总胆固醇水平均明显低于治疗前(P0.05),而干细胞治疗组的上述指标水平均明显低于常规治疗组(P0.05)。干细胞治疗组总有效率明显高于常规治疗组(P0.05)。治疗后超声显示内部回声均匀,实质回声一致,肝动脉连续性比较好,走行规则。治疗后两组肝动脉峰值速度和血流量较治疗前明显上升(P0.05),阻力系数较治疗前明显下降(P0.05),而干细胞治疗组明显优于常规治疗组(P0.05)。结论脐血干细胞移植治疗肝硬化可取得较理想的治疗效果,通过彩色多普勒超声观察肝动脉系统的血流动力学变化,对临床评价脐血干细胞移植治疗肝硬化失代偿期的效果具有重要的意义。
[Abstract]:Objective to evaluate the value of color Doppler ultrasound in the treatment of decompensated cirrhosis with umbilical cord blood stem cell transplantation. Methods 100 patients with decompensated cirrhosis were divided into conventional treatment group and stem cell treatment group according to their wishes. The routine treatment group was treated with routine liver protection, and the stem cell group was treated with umbilical cord blood stem cell transplantation. Before and after treatment, the liver function and blood lipid function of all the patients were measured on an empty stomach, and the blood flow was monitored by color Doppler ultrasound. Results after treatment, alanine aminotransferase, alanine aminotransferase, triacylglycerol, alanine aminotransferase, alanine aminotransferase, triacylglycerol, The total cholesterol level was significantly lower than that before treatment, while the above indexes in stem cell treatment group were significantly lower than those in routine treatment group. The total effective rate of stem cell treatment group was significantly higher than that of routine treatment group. The echo of parenchyma is consistent, and the continuity of hepatic artery is good. After treatment, the peak velocity and blood flow of hepatic artery in the two groups were significantly increased compared with those before treatment, and the resistance coefficient was significantly lower than that before treatment, while the stem cell treatment group was obviously superior to the routine treatment group. Conclusion Cord blood stem cell transplantation is effective in the treatment of umbilical cord blood stem cell transplantation. The treatment of liver cirrhosis can achieve a better therapeutic effect. Observing the hemodynamic changes of hepatic artery system by color Doppler ultrasound is of great significance for the clinical evaluation of umbilical cord blood stem cell transplantation in the treatment of decompensated liver cirrhosis.
【作者单位】：湖北省武汉市第一医院消化内科;湖北省武汉市第一医院超声影像科;
【基金】：湖北省自然科学基金资助项目(编号:2013CFC115)
【分类号】：R445.1;R575.2

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