基于NASIC程序的纳米金辐射增敏效应模拟研究

发布时间：2018-03-22 19:25

  本文选题：纳米金粒子　切入点：蒙特卡罗　出处：《强激光与粒子束》2017年12期 　论文类型：期刊论文

【摘要】：纳米金粒子(GNP)应用为放疗辐射增敏剂是目前国际上的一个研究热点。使用自主研发的纳剂量生物物理蒙特卡罗程序(NASIC),模拟研究了光子照射下细胞环境中GNP的物理增敏效应和生物增敏效应。通过建立单个GNP位于细胞核中心以及多个GNP在细胞内四种理想分布的GNP-细胞模型,分析光子能量、GNP粒子尺寸和分布对能量沉积、DNA辐射损伤和细胞存活的影响。结果表明,GNP附近约2μm的范围内具有能量沉积的增强效应,这主要是因为GNP内光电效应作用数目的显著增加。不同条件下细胞核内能量沉积、DSB数目和细胞存活分数增强效应的变化规律基本一致,但增强因子呈递减趋势,三种评价指标增强因子的最大值分别为1.55,1.32和1.14。光子能量为40keV、GNP直径为100nm并分布在细胞核表面时,相比其他参数组合具有较高的物理和生物辐射增敏效应。
[Abstract]:The application of nanocrystalline gold particle GNP as radiosensitizer is a hot topic in the world. The physics of GNP in cell environment under photon irradiation was simulated by using the self-developed nano-dose biophysical Monte Carlo program (NASCC). Through the establishment of a single GNP located in the nuclear center and four ideal distribution of GNP in the cell, we established the GNP-cell model. The effects of the size and distribution of photonic energy (GNP) particles on DNA radiation damage and cell survival in energy deposition were analyzed. The results showed that there was an enhanced effect of energy deposition in the range of about 2 渭 m near GNP. This is mainly due to the significant increase in the number of photovoltaic effects in GNP. The changes of the number of DSBs in the nucleus and the enhancement effect of cell survival fraction were basically consistent under different conditions, but the enhancement factors showed a decreasing trend. The maximum value of enhancement factor of the three evaluation indexes was 1.55g 1.32 and 1.14.The photon energy of 40keV GNP was 100nm and distributed on the nuclear surface, which had higher physical and biological radiosensitization effect than other parameter combinations.
【作者单位】： 清华大学工程物理系;清华大学粒子技术与辐射成像教育部重点实验室;同方威视技术股份有限公司;
【基金】：国家自然科学基金项目(11375103) 国家重点基础研究计划项目(2016YFC0904600)
【分类号】：R730.55
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