产前胎儿颈后透明层和颈后皮褶厚度联合母体血清学检测筛查胎儿染色体异常的临床价值

发布时间：2018-03-23 17:51

本文选题：产前筛查　切入点：超声软指标　出处：《中国现代医学杂志》2017年21期

【摘要】：目的探讨产前超声软指标(USM)颈后透明层(NT)与颈后皮褶厚度(NF)联合母体甲胎蛋白(AFP)与绒毛膜促性激素β亚单位(β-HCG)检测筛查胎儿染色体异常的临床价值。方法选取2013年4月-2015年3月在该院产检的2 402例孕妇为研究对象,依据染色体异常情况,分析孕妇孕期超声软指标N T、N F及其血清学检测结果与胎儿染色体异常的关系。结果 2 402例孕妇中,单一血清学筛查为高风险者198例,单一USM高风险者76例,两者并存高风险43例,共检出34例染色体异常胎儿。其中若单依据血清学筛查,其敏感性80.0%、特异性91.0%;若单依据USM筛查,其敏感性57.1%、特异性95.8%,若联合两者进行筛查,其敏感性97.1%、特异性99.6%。结论超声软指标NT、NF与血清学筛查联用有助于提高染色体异常胎儿早期筛查的敏感性及特异性。
[Abstract]:Objective to explore the clinical value of prenatal ultrasound soft index (USM), posterior transparent layer of the neck (NTT) and posterior cervical skin fold thickness (NFN) combined with maternal alpha-fetoprotein (AFP) and chorionic gonadotropin 尾 subunit (尾 -HCG) in the screening of fetal chromosomal abnormalities. Methods 2013. From April 2000 to March 2015, 2,402 pregnant women were examined in the hospital. According to chromosomal abnormality, the relationship between fetal chromosomal abnormality and ultrasonic soft index N TTN F in pregnancy and its serological results were analyzed. Results among the 2 402 pregnant women, 198 were at high risk of single serological screening. A total of 34 fetuses with chromosomal abnormalities were detected in 76 cases with high risk of single USM and 43 cases with both. If serological screening alone, the sensitivity is 80.0 and the specificity is 91.0, and if only based on USM screening, the sensitivity is 80.0 and the specificity is 91.0. The sensitivity is 57.1 and the specificity is 95.8.The sensitivity is 97.1and the specificity is 99.6.Conclusion the combination of NTNF and serological screening is helpful to improve the sensitivity and specificity of early fetal screening for chromosomal abnormalities.
【作者单位】：广东省惠州市中心人民医院超声医学科;
【分类号】：R445.1;R714.5

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