CEUS评价大鼠肝泡状棘球蚴病灶血流灌注的动态演变

发布时间：2018-03-24 11:49

  本文选题：泡状棘球蚴　切入点：肝　出处：《中国介入影像与治疗学》2017年09期

【摘要】：目的探讨CEUS评价不同时期大鼠肝泡状棘球蚴病(HAE)血流灌注的价值。方法采用CEUS观察70只成功感染HAE的大鼠在接种后不同时期(9、28、50周)的血流灌注特征,并与病理结果对照。结果接种9周时55个(55/70,78.57%)病灶表现为高回声,15个(15/70,21.43%)病灶表现为混合性回声,病理表现为乳白色单/多囊泡样结构。随接种时间的延长(28、50周),病灶最大径逐渐增大,病灶内部实性成分及钙化灶逐渐增多,部分病灶可出现液化坏死。镜下病灶周边纤维组织逐渐增厚,周边见微血管聚集区。接种9周时CEUS显示病灶呈环状强化及分隔样强化,28周及50周时呈环状强化或伴细线样强化及无强化。CEUS后病灶边缘增强带最大宽度与病灶最大径比值随接种时间延长而逐渐减小(P=0.02)。结论接种后不同时期大鼠HAE病灶的超声征象渐趋复杂,坏死区及钙化灶增加,CEUS可显示不同时期病灶周边及内部的血流灌注特征。
[Abstract]:Objective to evaluate the value of CEUS in evaluating the perfusion of hepatic alveolar echinococcosis (HAE) in rats at different stages. Methods CEUS was used to observe the blood perfusion characteristics of 70 rats successfully infected with HAE at different stages (2850 weeks after inoculation). Results at 9 weeks after inoculation, 55 lesions showed hyperechoic and 15 / 15 / 70 / 70 / 21.43) lesions showed mixed echo, and 55 / 55 / 70 / 78.57) lesions showed hyperechoic, and 15 / 15 / 70 / 70 / 21.43) lesions showed mixed echo. With the extension of inoculation time of 2850 weeks, the maximum diameter of the lesion gradually increased, and the solid composition and calcification of the lesion increased gradually. Liquefaction necrosis may occur in some lesions. The fibrous tissue around the lesion is gradually thickened under microscope. Peripheral microvascular agglomeration. At 9 weeks of inoculation, CEUS showed the lesion as annular enhancement and septoid enhancement at 28 weeks and 50 weeks with ring enhancement or thin line enhancement and no enhancement. CEUS showed the maximum width of the margin enhancement zone and the maximum lesion size after inoculation. The ratio of large diameter to diameter decreased gradually with the time of inoculation. Conclusion the ultrasonic signs of HAE lesions become more and more complicated in different periods after inoculation. Enhanced CEUs in necrotic areas and calcified foci could display the perfusion characteristics around and inside the lesions at different stages.
【作者单位】： 新疆医科大学第一附属医院超声诊断科;新疆医科大学第一附属医院新疆包虫病基础医学重点实验室;新疆医科大学第一附属医院影像中心;
【基金】：国家自然科学基金(81460267)
【分类号】：R445.1;R532.3
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