动态对比增强对预测胶质瘤级别的Meta分析

发布时间：2018-03-25 07:21

本文选题：胶质瘤　切入点：分级　出处：《山西医科大学》2017年硕士论文

【摘要】：目的:调查动态对比增强磁共振检查所获得的定量参数区别低级别胶质瘤和高级别胶质瘤的能力。方法:以“胶质瘤”、“星形细胞瘤”、“神经上皮性肿瘤”、“动态对比增强”、“DCE”、“dynamic contrast enhanced”“glioma”“astrocytoma”“astrocytic tumour”“neuroepithelial neoplasms”“neuroepithelial tumour”为关键词,在中国知网(CNKI)、万方数据库、维普数据库、PubMed、Science Direct、Cochrane Library中检索国内外公开发表的有关动态对比增强对胶质瘤分级诊断的文献,使用Rev Man5.3软件对文献进行Meta分析。结果:一共检索到317篇文献,最终有10篇关于动态对增强磁共振检查在胶质瘤分级诊断中应用的文献纳入分析,累计病例数为419例。Meta分析结果如下:(1)LGG肿瘤实质区的Ktrans值低于HGG肿瘤实质区的Ktrans值WMD=-0.14,95%CI[-0.16,-0.11],结果有统计学意义;(2)LGG肿瘤实质区的Ve值低于HGG肿瘤实质区的Ve值WMD=-0.21,95%CI[-0.29,-0.15],结果有统计学意义;(3)LGG肿瘤实质区的Vp值低于HGG肿瘤实质区的Vp值WMD=-0.03,95%CI[-0.07,-0.00],结果无统计学意义;(4)LGG肿瘤实质区的Kep值低于HGG肿瘤实质区的Kep值WMD=-0.36,95%CI[-1.06,0.35],结果无统计学意义。结论:(1)动态对比增强所获得的定量参数Ktrans、Ve有助于确定胶质瘤的级别,LGG肿瘤实质区的Ktrans、Ve低于HGG肿瘤实质区的Ktrans、Ve。(2)由于我们纳入的各项研究间存在异质性,某些研究质量偏低,所以还需要进一步的高质量大样本的病例系列研究,从而对Ktrans、Ve、Vp、Kep在胶质瘤分级中的应用进行更为系统、全面、深入的评价。
[Abstract]:Objective: to investigate the ability of dynamic contrast-enhanced magnetic resonance imaging (Mr) to distinguish between low-grade gliomas and high-grade gliomas. Methods: by using "glioma", "astrocytoma", "neuroepithelial tumor", "dynamic contrast" Enhancement, "DCE," "dynamic contrast enhanced," "glioma," "astrocytoma," "astrocytic tumour," "neuroepithelial neoplasms," "neuroepithelial tumour," The literature published at home and abroad on dynamic contrast enhancement in the diagnosis of glioma grading was searched in CNKI, Wanfang database, Webb database and PubMedMed Science Direct Cochrane Library. Meta analysis was performed with Rev Man5.3 software. Results: a total of 317 papers were retrieved, and 10 papers were included in the analysis on the application of dynamic contrast-enhanced magnetic resonance imaging in the grading diagnosis of gliomas. The results of meta-analysis are as follows: the Ktrans value of the tumor parenchyma of 1: 1 / HGG is lower than that of the Ktrans of HGG [-0.16 + -0.11]. The results show that the value of ve in the tumor parenchyma is lower than that in the tumor of HGG [WMD-0.21995 CI [-0.29h-0.15]. The value of VP in the tumor parenchyma of HGG was lower than that in the parenchyma of HGG [-0.07 + -0.00]. The results showed that the Kep value of the tumor parenchyma of HGG was lower than the value of Kep of HGG. There was no statistical significance. Conclusion there is no statistical significance. The quantitative parameter KtransVe obtained is helpful to determine the grade of gliomas. The KtransVe of the GG tumor parenchyma is lower than that of the HGG. Because of the low quality of some studies, it is necessary to further study the case series of high quality and large sample, so as to evaluate the application of VpP Kep in glioma classification more systematically, comprehensively and thoroughly.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R739.41

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