三阴性乳腺癌与HER-2过表达型乳腺癌病理、MRI动态增强特征及ADC值分析

发布时间：2018-03-25 23:31

本文选题：乳腺癌　切入点：磁共振成像　出处：《新疆医科大学》2014年硕士论文

【摘要】：目的：对三阴性乳腺癌及HER-2过表达型乳腺癌的病理、磁共振动态增强特征及ADC值进行探讨及分析,提高对两者病理、磁共振特征的认识和判断。方法：对经免疫组化证实为三阴性乳腺癌的68名患者及55例HER-2过表达型乳腺癌患者的病理、MR动态增强特征进行分析,测量ADC值,同时进行统计学比较。结果：68例TNBC中浸润性导管癌59例,髓样癌5例,55例HER-2过表达型乳腺癌中浸润性导管癌39例,导管原位癌13例,两组乳腺癌在浸润性导管癌、髓样癌、导管原位癌比较有差异。TNBC在MRI上大多表现为类圆形、边缘光整、环状强化及相对高的ADC值,HER-2过表达性乳腺癌在MRI上大多表现为不规则形、边缘毛刺、不均匀强化,相对低的ADC值。而在患者年龄,是否肿块及TIC上,差异无统计学意义(P0.05)。结论：TNBC多为浸润性导管癌及髓样癌,HER-2过表达型乳腺癌多为浸润性导管癌及导管原位癌,乳腺MR1动态增强形态学特征中病灶的形状、边缘、强化方式及ADC值对诊断TNBC及HER-2过表达性乳腺癌具有一定参考价值。
[Abstract]:Objective: to study and analyze the pathology, dynamic enhancement characteristics and ADC value of triple negative breast cancer and HER-2 overexpression breast cancer. Methods: dynamic contrast-enhanced MRI features of 68 patients with triple-negative breast cancer and 55 patients with HER-2 overexpression were analyzed and ADC values were measured. Results among 68 cases of TNBC, 59 cases of invasive ductal carcinoma, 5 cases of medullary carcinoma and 55 cases of HER-2 overexpression breast cancer, 39 cases of invasive ductal carcinoma, 13 cases of ductal carcinoma in situ, two groups of breast cancer in invasive ductal carcinoma, medullary carcinoma. Ductal carcinoma in situ most of the breast cancer on MRI appeared round, edge smooth, circular enhancement and relatively high ADC value of HER-2 over-expression breast cancer on MRI most of the irregular shape, edge burr, uneven enhancement. There was no significant difference in age, mass and TIC in patients with ADC. Conclusion the majority of invasive ductal carcinoma and medullary carcinoma are infiltrative ductal carcinoma and breast cancer with HER-2 overexpression in situ. The shape, edge, enhancement mode and ADC value of the lesions in the dynamic enhanced morphological features of breast MR1 have certain reference value for the diagnosis of TNBC and HER-2 overexpression breast cancer.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2;R737.9

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