左侧乳腺癌保乳术后不同调强放疗计划的剂量学研究

发布时间：2018-03-26 09:08

本文选题：乳腺癌　切入点：乳房保留术　出处：《安徽医科大学学报》2017年07期

【摘要】：目的比较左侧乳腺癌保乳术后不同调强放疗技术的剂量学差异。方法选取14例左侧乳腺癌保乳术后患者,分别设计4野静态调强(4F-IMRT)、混合调强(Hy-IMRT)和2个部分弧长容积旋转调强放疗(VMAT)计划,并比较3组计划的计划靶区(PTV)、危及器官和正常组织剂量参数以及治疗效率的差异。结果 3组计划PTV的最小剂量、平均剂量(Dmean)、适形度指数和V_(105)相差不大,但最大剂量、均匀性指数和V_(110)差异有统计学意义(P0.05),其中4FIMRT的靶区剂量分布最优。不同计划患侧肺V_5、V_(10)、V_(15)、Dmean以及心脏的V_(10)、V20差异有统计学意义(P0.05),HyIMRT患侧肺和心脏的剂量参数优于4F-IMRT和VMAT计划。Hy-IMRT靶区外正常组织的V_5、V_(10)明显优于其它两种计划(P0.05)。4F-IMRT所需机器跳数(MU)最多,而VMAT的治疗时间最短。结论 4F-IMRT在降低计划靶区高剂量区体积和提高剂量均匀性等方面有明显的优势;HyIMRT对左肺、右肺、心脏等危及器官保护较好,治疗所需的MU也最少;VMAT可以缩短治疗时间,提高患者舒适性和放疗工作效率。
[Abstract]:Objective to compare the dosimetric differences of different intensity modulated radiotherapy (IMRT) techniques in patients with left breast cancer after breast conserving operation. Methods 14 patients with left breast cancer after breast conserving surgery were selected. Four field static intensity modulation (4F-IMRT), mixed intensity modulation (Hy-IMRTT) and two partial arc length volume rotational intensity modulated radiotherapy (VMATT) schemes were designed respectively. The difference of dose parameters and therapeutic efficiency between the three groups was compared. Results the minimum dose, mean dose, conformability index and maximum dose of PTV in the three groups were similar, but the maximum dose was the highest dose. There were significant differences between the homogeneity index and the VARL 110), in which the target area of 4FIMRT was the best dose distribution. There were significant differences in the dose parameters of the lung and heart of the affected side of the affected lung, V5 and VMAT. The dose parameters of the lung and the heart of the affected side were better than those of the 4F-IMRT and VMAT plans. The number of machine hops required by normal tissues outside the target area of Hy-IMRT was significantly higher than that of the other two schemes (P0.05U. 4F-IMRT). Conclusion 4F-IMRT has obvious advantages in reducing the volume of high dose area and improving the uniformity of dose in the planned target area. HyIMRT has good protection for the dangerous organs such as left lung, right lung, heart and so on. MU and VMAT can shorten the time of treatment and improve the comfort and efficiency of radiotherapy.
【作者单位】：安徽医科大学附属省立医院放疗科;安徽医科大学生命科学学院生物医学工程系;
【基金】：安徽省高校省级自然科学研究项目(编号:KJ2010B380)
【分类号】：R730.55;R737.9

【相似文献】