老年人脑白质病变相关性跌倒的脑静息态功能磁共振成像

发布时间：2018-03-27 11:52

本文选题：白质　切入点：意外跌倒　出处：《中国医学影像技术》2016年11期

【摘要】：目的探讨老年人脑白质病变(WMLs)相关性跌倒患者的脑静息态fMRI(rs-fMRI)特征。方法前瞻性选取本院60岁以上的WMLs患者40例,均接受rs-fMRI检查,根据Tinetti平衡和步态量表划分为跌倒风险组(Tinetti25,n=11)及对照组(Tinetti≥25,n=29)。应用SPM 8软件进行图像处理,识别跌倒风险患者脑网络内及网络间的功能连接异常,并与简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分进行相关性分析。结果跌倒风险组的MMSE(t=4.04,P0.01)及MoCA(t=3.88,P0.01)量表评分低于对照组。与对照组比较,跌倒风险组的记忆网络(MeN)脑功能连接减弱(t=2.87,P=0.01);带状盖任务控制网络(CON)和腹侧注意网络(VAN)的功能连接减弱(t=2.59,P=0.01);默认网络(DMN)和额顶任务控制网络(FPN)的功能连接增强(t=-2.13,P=0.04),所有WMLs患者的MeN网络内功能连接与MoCA评分(r=0.39,P=0.01)呈正相关;DMN和FPN功能连接与MMSE(r=-0.40,P=0.01)及MoCA(r=-0.37,P=0.02)呈负相关。结论具有跌倒风险的WMLs患者存在脑网络内及网络间的功能连接异常,并与其认知功能改变存在一定的相关性。
[Abstract]:Objective to investigate the characteristics of resting fMRIr rs-fMRI in elderly patients with WMLsrelated falls. Methods Forward-looking 40 WMLs patients over 60 years old in our hospital were selected, all of them were examined by rs-fMRI. According to the Tinetti balance and gait scale, the patients at risk of falls were divided into two groups: Tinetti (25) and control group (n = 29). SPM 8 software was used for image processing to identify the abnormal functional connections in and between the brain networks of patients at risk of falling. The correlation analysis was made with the MMSE scale and the Montreal Cognitive Assessment scale (MOCA). Results the scores of MMSEt0. 01 and MoCAT 3. 88 P0. 01) in the fall risk group were lower than those in the control group, and compared with those in the control group. In the fall risk group, the functional connections of the memory network (MeN) and the frontal top task control network (FPN) were weakened, and the functional connections of the band cover task control network (conn) and the ventral attention network (VANN) weakened; the default network (DMNs) and the forehead top task control network (FPN) enhanced the functional connections between the two networks. There was a positive correlation between the functional connections within the MeN network and the MoCA score of 0.39 P0. 01). There was a negative correlation between the functional connections of DMN and FPN and the MMSE r-0.40 P0. 01) and the MMSE r-0.37 P0. 02). Conclusion there are abnormal functional connections in and between the brain networks in WMLs patients with fall risk. And there is a certain correlation with the change of cognitive function.
【作者单位】：首都医科大学附属北京天坛医院神经影像中心;首都医科大学附属北京天坛医院神经精神医学与临床心理科;南方医科大学生物医学工程学院;中国科学院自动化研究所脑网络组中心;
【基金】：[基金项目]首都临床特色应用研究与成果推广(Z151100004015127)
【分类号】：R445.2;R742

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