高频超声影像肝脏包膜几何特征定量评价患者肝硬化程度

发布时间：2018-03-28 05:19

本文选题：几何特征　切入点：超声检查　出处：《中国医学影像技术》2015年12期

【摘要】：目的探讨基于高频超声图像的肝脏包膜线几何特征定量评价乙型肝炎肝硬化程度的可行性。方法收集48例轻、中、重度乙型肝炎肝硬化患者(轻度肝硬化组、中度肝硬化组、重度肝硬化组)及20名正常志愿者(正常对照组)肝包膜的二维高频声像图,结合人工监督与梯度优化方法获取包膜线及其形状控制点,提取包膜线的连续线段数、形状控制点的夹角均值及夹角方差3个参数,分别评估肝包膜轮廓线的连续性和平滑度。结果随着肝硬化程度的逐渐加重,连续线段长度和达到成像切面总宽度的80%时所需要的线段数量逐渐增多,夹角均值和方差也逐渐增大;除中、重度肝硬化组间的线段数量差异无统计学意义外(P=0.149),其余组别各参数的比较差异均有统计学意义(P0.05)。结论肝包膜的几何特征分析可较准确地诊断不同程度肝硬化,可望为肝硬化的非侵入性评估提供一种量化处理方法。
[Abstract]:Objective to investigate the feasibility of quantitative evaluation of liver cirrhosis based on high frequency ultrasound. Methods 48 patients with mild, moderate and severe hepatitis B cirrhosis (mild cirrhosis, moderate cirrhosis, moderate cirrhosis) were collected. Two dimensional high frequency sonogram of liver capsule of 20 normal volunteers (severe cirrhosis group) and normal control group were used to obtain the envelope line and its shape control points by combining with artificial supervision and gradient optimization, and the number of continuous segments of the capsule line was extracted. The angle mean and angle variance of the shape control point were used to evaluate the continuity and smoothness of the hepatic capsule contour. The number of segments needed for the length of the continuous segment and the number of segments needed to reach the total width of the imaging section increased gradually, and the mean and variance of the angle increased gradually; except in the middle, There was no significant difference in the number of line segments among patients with severe liver cirrhosis. There was no significant difference in the number of lines between the two groups, and there were significant differences in the parameters of the other groups. Conclusion the geometric characteristics of hepatic capsule can be used to diagnose liver cirrhosis of different degrees accurately. It is expected to provide a quantitative treatment for non-invasive assessment of cirrhosis.
【作者单位】：第二军医大学附属长征医院超声科;复旦大学计算机科学技术学院;上海海事大学信息工程学院;
【基金】：国家自然科学基金青年项目(81101105)
【分类号】：R575.2;R445.1

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