短时中等强度有氧运动对脑静息态局部一致性活动影响的初步研究

发布时间：2018-03-29 00:26

本文选题：急性有氧运动　切入点：静息态功能磁共振成像技术　出处：《华东师范大学》2014年硕士论文

【摘要】：行为学和神经认知影像学研究表明,急性锻炼和慢性锻炼都能改变大脑神经活动模式,改善认知功能和情绪状态,有助于个体通过调整自身功能来适应环境的变化,提高生活质量和幸福感。近年来,随着神经影像技术的发展,静息态功能磁共振成像技术在研究人脑神经活动方面的应用价值得到认可。本研究结合运动干预方法,采用静息态功能磁共振成像技术,探讨短时中等强度有氧运动对大脑神经局部一致性活动的影响,进一步解释有氧运动改善认知功能和情绪状态的神经基础。采用被试内运动干预实验设计。选择15名在校女大学生为研究对象,分别采集两次静息态功能磁共振数据：一次为静息状态下休息30分钟的运动干预前；一次为30分钟蹬功率自行车的短时中等强度有氧运动干预后。采用单变量分析方法,基于像素的全脑局部一致性(regional homogeneity, ReHo)指标,分别计算运动干预前和干预后大脑神经活动的局部一致性值即ReHo值。干预前和干预后单样本T检验结果发现,大脑静息态神经活动干预前和干预后都具有明显的局部一致性,其中额叶、顶叶脑区ReHo值有统计学意义(P0.0001,未校正)。运动干预后与干预前配对T检验结果发现,运动干预后局部大脑神经活动选择性增强,具体表现为运动后右侧前扣带回、右侧前岛,右侧背外侧前额叶,两侧楔前叶,两侧顶下小叶及左侧楔叶脑区ReHo值增强显著,具有统计学意义(P0.05, AlphaSim校正)。结果表明,急性中等强度有氧运动选择性增强脑静息态局部一致性神经活动,这与有氧锻炼影响执行功能和情绪状态的行为学和任务态神经认知影像学研究结果相吻合。静息态功能磁共振成像为研究体育锻炼的神经作用机制提供了一种新的有效途径。
[Abstract]:Behavioral and neurocognitive imaging studies have shown that both acute and chronic exercise can change the pattern of neural activity in the brain, improve cognitive function and emotional state, and help individuals adapt to environmental changes by adjusting their own functions. In recent years, with the development of neuroimaging technology, the application value of resting functional magnetic resonance imaging in the study of human brain nerve activity has been recognized. By using resting functional magnetic resonance imaging (fMRI), the effect of short term moderate intensity aerobic exercise on the local consistent activity of cerebral nerve was studied, and the neural basis of aerobic exercise for improving cognitive function and emotional state was further explained. 15 female college students were selected as the research subjects, and two resting fMRI data were collected: one time before the exercise intervention for 30 minutes in the resting state; The regional homogeneities (ReHox) index of regional homogenicity (ReHox) of the whole brain based on pixel local consistency was analyzed by univariate analysis after a 30 minute short time moderate intensity aerobic exercise intervention. The local consistency value of cerebral nerve activity was calculated before and after exercise intervention, namely ReHo value. The results of single sample T test before and after intervention showed that there was significant local consistency before and after intervention. The ReHo value of frontal lobe and parietal lobe brain area was significantly higher than that of control group (P 0.0001). The results of paired T test before and after exercise intervention showed that the selective enhancement of local cerebral nerve activity was found after exercise intervention, which was manifested as right anterior cingulate gyrus after exercise. The ReHo values of right anterior island, right dorsolateral prefrontal lobe, bilateral precuneiform lobe, bilateral inferior parietal lobule and left cuneate lobe were significantly enhanced (P 0.05, AlphaSim correction). The results showed that acute moderate intensity aerobic exercise selectively enhanced local consistent neural activity in resting brain. This is consistent with the results of behavioral and task-based neurocognitive imaging studies on the effects of aerobic exercise on executive function and emotional state. Resting functional magnetic resonance imaging provides a new and effective way to study the neuromechanism of physical exercise.
【学位授予单位】：华东师范大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2

【参考文献】