DWI定量评价非压迫性神经根炎微创治疗价值的动物实验研究

发布时间：2018-03-30 10:24

本文选题：腰椎间盘突出　切入点：扩散加权成像　出处：《临床放射学杂志》2015年03期

【摘要】：目的探讨扩散加权成像(DWI)技术对腰椎非压迫性神经根炎不同微创治疗术后变化定量评价的价值。方法中国小型猪12只CT导向下非压迫性神经根炎造模成功14天后,根据治疗方法不同随机分为4组。分别于实验猪的L2~3、L3~4及L4~5双侧神经根旁注入相应物质进行治疗。每组分别于术前、术后3天、7天及15天对实验猪进行MRI扫描,扫描完成后处死1只实验动物,取相应双侧神经根行免疫组织化学检查。分析各组于术前、术后3天、7天、15天神经根表观扩散系数(ADC)值及神经根CD8阳性T淋巴细胞计数评分的变化,以及两者之间的相关性。结果 A、B、C、D组治疗前、治疗后3天、7天、15天神经根平均ADC值及神经根淋巴细胞计数评分均呈下降趋势(P0.05);A、B、C、D组神经根ADC值与神经根淋巴细胞计数评分均呈正相关。结论不同治疗方法均能使神经根炎得到较好地改善,DWI技术能对腰椎非压迫性神经根炎微创治疗术后变化进行定量评价。
[Abstract]:Objective to evaluate the value of diffusion-weighted imaging (DWI) technique in the quantitative evaluation of postoperative changes in non-compression neuritis of lumbar vertebrae after different minimally invasive treatment. Methods after 14 days of successful modeling of non-compression neuritis under CT guidance in 12 Chinese miniature pigs. According to the different treatment methods, the pigs were randomly divided into 4 groups. The corresponding substances were injected into the bilateral nerve roots of the experimental pigs, respectively. The MRI scans were performed on the experimental pigs before operation, 3 days after operation, 7 days and 15 days after operation, respectively. After scanning, one experimental animal was killed and the corresponding bilateral nerve roots were taken for immunohistochemical examination. The changes of the apparent diffusion coefficient of nerve root (ADCC) and the score of CD8 positive T lymphocyte count in nerve root were observed on the 3rd day and 7th day after operation, and the correlation between them was also found. Results before treatment, there was no significant difference between the two groups. The average ADC value of nerve root and the score of lymphocyte count of nerve root were decreased on the 3rd day and 7th day after treatment. Conclusion the ADC value of nerve root and the lymphocyte count score of nerve root in group P0.05AZB CU D are positively correlated with the score of lymphocyte count of nerve root. Conclusion the different treatment methods can increase the number of nerve root lymphocytes. The improved DWI technique can be used to quantitatively evaluate the postoperative changes of non-compressed lumbar spondylolitis after minimally invasive treatment.
【作者单位】：成都大学附属医院放射科;川北医学院附属医院放射科;
【分类号】：R445.2;R687.3

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