高频超声监测内毒素兔心脏与肾脏血流动力学变化

发布时间：2018-03-31 06:38

本文选题：高频超声　切入点：内毒素血症　出处：《川北医学院》2014年硕士论文

【摘要】：目的：通过使用高频超声，连续监测不同剂量新西兰大白兔内毒素血症模型心脏与肾脏的血流动力学变化。方法：25只健康成年雄性新西兰大白兔，采用随机数字表法，分为生理盐水组（5只）、5μg/kg内毒素组（10只）和500μg/kg内毒素组（10只）。经耳缘静脉单次泵注脂多糖(LPS)建立内毒素血症模型。在输注生理盐水或LPS之前、后1、2、3、4、5、6h观察其生命体征（心率、血压、呼吸频率、体温），采用超声监测心脏血流动力学变化指标（LVEF，LVFS， LVPWd，LVPWs，，IVSd，IVSs，LVIDd， SV，CO，MV VEmax及AV Vmax），监测肾脏血流动力学变化指标（PSV，EDV，RI，PI）。在6个小时的监测期完成后处死所有兔子。结果：在实验监测期间，生理盐水组与5μg/kg内毒素组以及500μg/kg内毒素组在生命体征、心脏血流动力学改变、肾脏血流动力学改变上均存在统计学差异(P0.05)，三组间存活率不存在统计学差异(P0.05)。结论：不同剂量内毒素组其生命体征、超声监测下的心脏与肾脏血流动力学变化存在显著差异。其血流动力学变化与LPS的剂量直接相关。
[Abstract]:Aim: to continuously monitor the hemodynamic changes in the heart and kidney of endotoxemia model of New Zealand rabbits with different doses by high frequency ultrasound. Methods Twenty five healthy adult male New Zealand white rabbits were randomly assigned, The model of endotoxemia was established by injecting lipopolysaccharide (LPS) through auricular vein. Before the infusion of normal saline or LPS, the vital signs (heart rate, blood pressure) were observed for 6 hours before infusion of normal saline or LPS. Respiratory frequency, body temperature, cardiac hemodynamic indexes (LVEFV), LVPWS (LVPWS), IVSs (IVSsl) LVIDd, SVVCOMV VEmax and AV Vmax#en0# were monitored by ultrasound. All rabbits were killed after 6 hours of monitoring. Results: during the period of experimental monitoring, the changes of vital signs and cardiac hemodynamics were observed in saline group, 5 渭 g/kg endotoxin group and 500 渭 g/kg endotoxin group. There were significant differences in renal hemodynamic changes between the three groups (P 0.05), and there was no significant difference in survival rate among the three groups. Conclusion: there are significant differences between the vital signs and the changes of heart and kidney hemodynamics monitored by ultrasound in different dose endotoxin groups, and the hemodynamic changes are directly related to the dose of LPS.
【学位授予单位】：川北医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.1;R459.7

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