超声引导冷冻对局部瘢痕与炎症的影响及在乳腺良性病变的应用

发布时间：2018-03-31 07:44

本文选题：冷冻消融　切入点：射频消融　出处：《福建医科大学》2014年硕士论文

【摘要】：目的比较冷冻及射频消融术后新西兰兔肌肉局部炎症及瘢痕形成情况。方法18只健康雄性新西兰兔随机分为冷冻（CR）组、射频(RF)组和对照组，分别对腿部肌肉进行超声引导冷冻及射频消融。ELISA法检测血浆TNF-α、IL-6水平，免疫组织化学检测损伤肌肉TGF-β1表达,术后瘢痕美容评分，HE染色观察局部炎症及瘢痕生成情况。结果与RF组相比，CR组血清IL-6和TNF-α峰值较早出现，，持续时间短，反应较轻；局部治疗部位TGF-β1免疫组化评分CR组较低（53±31.9与101.7±40.03，P0.01）。术后瘢痕美容评分，CR组均低于RF组（2.5±0.55与8.5±1.05，P0.01）。结论冷冻消融较射频消融引起局部组织炎症较轻且瘢痕形成较少。目的探讨超声引导冷冻介入治疗乳腺纤维腺瘤的应用价值。方法对6例乳腺纤维腺瘤患者（9个病灶）行超声引导冷冻介入消融术，治疗前及治疗后3、6、9、12个月超声观察乳腺纤维腺瘤体积变化、乳腺瘢痕美容评分、疼痛量化评分。结果超声引导介入冷冻消融后的乳腺纤维腺瘤结节在治疗12个月后体积明显缩小（术后结节体积与术前比， P0.01），瘢痕美容评分（术前1.89±0.33，术后1.11±0.33，P0.01）及疼痛量化评分改善（术前3.60±1.51，术后1.44±1.01，P0.01）。结论超声引导介入冷冻消融术治疗乳腺纤维腺瘤是一种安全有效的方法
[Abstract]:Objective to compare the local inflammation and scar formation after cryopreservation and radiofrequency ablation in New Zealand rabbits. Methods Eighteen healthy male New Zealand rabbits were randomly divided into three groups: cryosurgery group, radiofrequency catheter catheter (RF) group and control group. The plasma TNF- 伪 IL-6 level was detected by ultrasound guided freezing and radiofrequency ablation. The expression of TGF- 尾 1 in injured muscle was detected by immunohistochemistry. Postoperative scar beauty score and HE staining were used to observe the local inflammation and scar formation. Results compared with RF group, the peak value of serum IL-6 and TNF- 伪 in CR group appeared earlier, the duration was shorter and the response was mild, and the immunohistochemical score of TGF- 尾 _ 1 in CR group was lower than that in RF group (53 卤31.9 and 101.7 卤40.03) P0.01.The postoperative scar beauty score in CR group was lower than that in RF group (2.5 卤0.55,8.5 卤1.05p 0.01). Conclusion cryoablation has less inflammation and less scar formation than radiofrequency ablation. Objective to evaluate the value of ultrasound-guided cryotherapy for breast fibroadenoma. Methods six patients (9 lesions) with breast fibroadenoma were treated with ultrasound-guided cryopreservation. The volume of fibroadenoma was measured by ultrasound before and after treatment. The volume of fibroadenoma, the beauty score of mammary scar and the quantitative score of pain were observed by ultrasound in 12 months. Results the volume of breast fibroadenoma nodule was significantly reduced after 12 months of treatment (the ratio of postoperative nodule volume to preoperative, P 0.01, scar beauty score (preoperative 1.89 卤0.33, postoperative 1.11 卤0.33, P 0.01)) and the change of quantitative pain score after ultrasound guided cryoablation of breast fibroadenoma. (3. 60 卤1. 51 before operation, 1. 44 卤1. 01 after operation, P 0. 01). Conclusion Ultrasound-guided interventional freezing ablation is a safe and effective method for the treatment of breast fibroadenoma.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.1;R622

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