多b值扩散加权成像评价恩度对人结肠癌裸鼠移植瘤疗效的实验研究

发布时间：2018-04-02 14:38

本文选题：结肠肿瘤　切入点：肿瘤移植　出处：《中国临床医学影像杂志》2016年07期

【摘要】：目的:探讨多b值扩散加权成像(DWI)无创性评价恩度对人结肠癌裸鼠移植瘤疗效的应用价值。方法:人结肠癌HT-29细胞株接种于48只裸鼠皮下,将48只裸鼠随机分为2组,对照组和恩度组各24只,分别于治疗前及治疗后2 d、7 d、14 d进行多b值扩散加权成像检查,观察表观扩散系数ADC值的变化,分别于治疗后2 d、7 d、14 d扫描后每组随机处死8只裸鼠进行病理免疫组化检查。结果:治疗后恩度组肿瘤ADC_(10b)、ADC_(high)值逐渐升高,ADC_(low)、ADC_(perf)值逐渐减低,治疗前后不同时间点4组观察指标差异比较有统计学意义(F值分别为29.986、23.742、21.598、63.973,P0.05),恩度组组内两两比较,ADC_(10b)、ADC_(high)、ADC_(perf)治疗前、治疗后2 d、7 d、14 d肿瘤观察指标差异有统计学意义,ADC_(low)除治疗后2 d、7 d组内比较差异无统计学意义,余组内两两比较观察指标差异有统计学意义。恩度组治疗后3个时间点ADC_(perf)与MVD结果呈正相关(P0.05),ADC_(10b)与MVD结果呈负相关(P0.05)。结论:多b值扩散加权成像扫描可以动态评价人结肠癌裸鼠移植瘤模型在药物治疗后肿瘤组织的变化,可以被认为是早期动态监测抗肿瘤血管生成药物疗效的参考指标。
[Abstract]:Objective: to evaluate the non-invasive value of multi-b diffusion-weighted imaging (DWI) in evaluating the therapeutic effect of Endor on transplanted human colon cancer in nude mice.There was no significant difference in tumor observation indexes between the two groups at 2 days and 7 days after treatment, but there was no significant difference between the two groups after 2 days of treatment, but there were significant differences between the two groups in the other two groups.In Endu group, there was a positive correlation between the results of MVD and MVD at 3 time points after treatment (P 0.05) and a negative correlation between the results of MVD and the results of MVD (P 0.05).Conclusion: Multi-b diffusion-weighted imaging can dynamically evaluate the changes of tumor tissue after drug therapy in nude mice transplanted with human colon cancer, and can be regarded as a reference index for early dynamic monitoring of anti-angiogenic drug efficacy.
【作者单位】：新疆医科大学第二附属医院影像中心;
【基金】：国家自然科学基金项目(NO.81360214)
【分类号】：R735.35;R445.2

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