超声剪切波弹性成像技术检测移植肝排斥反应的应用研究

发布时间：2018-04-04 14:26

本文选题：肝移植　切入点：移植物排斥　出处：《中国临床医学影像杂志》2017年07期

【摘要】：目的 :应用超声剪切波弹性成像技术(SWE)检测肝移植术后移植肝排斥反应患者肝硬度数值变化,探讨其临床应用价值。材料与方法:回顾肝移植术后2月内移植肝穿刺活检证实排斥反应患者19例,无排斥反应患者25例,应用SWE技术测量得到肝组织的杨氏模量,即硬度数据,同时检测其血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBil),以30例正常人为对照组,用统计学方法比较3组间杨氏模量、血清总胆红素、转氨酶的差异,并进行相关性分析。结果:正常对照组、移植肝正常组、排斥组之间杨氏模量均值Emean、最大值Emax、总胆红素、转氨酶均依次增加,3组间差别有统计学意义(P均0.05),单因素分析Emean与总胆红素呈正相关(r=0.544,P0.05)。结论 :SWE技术通过量化移植肝硬度大小,反映肝功能损伤程度,为临床提供客观诊疗依据。
[Abstract]:Objective: to investigate the value of ultrasonic shear wave elastic imaging (SWE) in detecting the liver hardness in patients with liver transplantation rejection.Materials and methods: 19 cases of rejection and 25 cases of non-rejection were confirmed by biopsy within 2 months after liver transplantation. The Young's modulus or hardness data of liver tissue were measured by SWE technique.Serum alanine aminotransferase (alt), aspartate aminotransferase (AST), total bilirubin (Tbilirubin) were detected. The differences of Young's modulus, serum total bilirubin and transaminase in 30 normal controls were compared by statistical method, and the correlation was analyzed.Results: the mean value of Young's modulus, maximum E max, total bilirubin and aminotransferase in normal control group, normal graft liver group and rejection group were increased in turn. There were significant differences among the three groups (P < 0.05). Univariate analysis showed that Emean was positively correlated with total bilirubin.Conclusion the degree of liver function injury can be reflected by the weight of graft liver by the technique of SWE, which can provide objective basis for clinical diagnosis and treatment.
【作者单位】：郑州人民医院超声科;
【分类号】：R445.1;R657.3

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