血管周围间隙扩大与脑微血管病变及其他血管危险因素的相关性

发布时间：2018-04-06 01:13

本文选题：血管周围间隙扩大　切入点：脑微血管病变　出处：《中国老年学杂志》2017年23期

【摘要】：目的评估扩大的血管周围间隙(EPVS)与脑微血管病变及其他血管危险因素的相关性。方法采用医学影像信息系统(华海PACS)系统搜集2014年5月至2015年6月间主因头晕入住神经内科并经影像学检查确诊为EPVS的患者100例。记录患者的临床与影像学资料,包括年龄、性别、EPVS的发生部位及分级、脑白质高信号(WMH)程度分级、脑萎缩程度分级及有无腔隙性脑梗死、高血压、糖尿病和高脂血症。采用单因素和多因素分析法确定EPVS与其他临床及影像学资料的相关性。结果 EPVS常见于老年人,男性稍多于女性。半卵圆中心和基底节区为EPVS最常见好发区,且以轻度为主。与轻度EPVS组相比,重度EPVS组发生重度WMH的比例更高。多因素分析显示,WMH为半卵圆中心和基底节区EPVS的独立预测因子,而年龄、高血压仅为基底节区EPVS的独立预测因子。结论 EPVS可提示造成小血管壁通透性改变的诸多潜在病理变化,应作为一个重要的脑微血管病变的标志物。
[Abstract]:Objective to evaluate the relationship between expanded perivascular space (EPVS) and cerebral microangiopathy and other vascular risk factors.Methods from May 2014 to June 2015, 100 patients who were admitted to the Department of Neurology for dizziness and diagnosed as EPVS by imaging examination were collected by the Medical Imaging Information system (PACSS).The clinical and imaging data of the patients were recorded, including age, sex, location and grade of EPVS, grade of WMHs, grade of cerebral atrophy and absence of lacunar infarction, hypertension, diabetes and hyperlipidemia.Univariate and multivariate analysis was used to determine the correlation between EPVS and other clinical and imaging data.Results EPVS was more common in the elderly than in the female.The center of semicircle and the basal ganglia were the most common predilection areas of EPVS, and were mainly mild.The incidence of severe WMH in severe EPVS was higher than that in mild EPVS.Multivariate analysis showed that WMH was an independent predictor of EPVS in the center of semiovale and basal ganglia, while age and hypertension were only independent predictors of EPVS in basal ganglia.Conclusion EPVS can indicate many potential pathological changes that cause the permeability change of small vessel wall and should be used as an important marker of cerebral microangiopathy.
【作者单位】：河北北方学院附属第一医院影像中心;
【分类号】：R445.2;R743

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