乳腺癌腋窝淋巴结声像图联合免疫组织化学与淋巴结转移的相关性研究

发布时间：2018-04-10 08:21

本文选题：乳腺癌　切入点：腋窝淋巴结转移　出处：《中国癌症杂志》2016年02期

【摘要】：背景与目的:乳腺癌腋窝淋巴结转移对于乳腺癌患者的预后及治疗方案的选择有重要的指导意义。本研究旨在探讨乳腺癌腋窝淋巴结声像图表现联合免疫组织化学与腋窝淋巴结转移的相关性。方法:回顾性分析应用超声检出的366例乳腺癌患者共计728枚腋窝淋巴结的声像图表现,采用单因素分析、多因素logistic回归及受试者工作特征(receiver operating characteristic,ROC)曲线分析的方法,分别检验乳腺癌腋窝淋巴结皮质最大厚度、长短径之比、皮髓质之比和淋巴结血流特征,联合乳腺癌术后免疫组织化学结果,研究其与病理学腋窝淋巴结转移的相关性。结果:依据单因素分析,腋窝淋巴结皮质最大厚度、长短径之比、血流特征以及乳腺癌病灶p53的阳性表达率与淋巴结转移有关(P0.05)。依据多因素分析及ROC分析,腋窝淋巴结皮质最大厚度是判定腋窝淋巴结转移的最佳指标。腋窝淋巴结皮质最大厚度大于3 mm的患者,其乳腺癌病灶的p53阳性表达率(42.78%)明显高于皮质最大厚度小于等于3 mm的患者(25.82%),差异有统计学意义(P0.01)。结论:乳腺癌腋窝淋巴结声像图表现联合免疫组织化学评价腋窝淋巴结转移,对乳腺癌的临床诊疗方法选择具有重要价值。
[Abstract]:Background & objective: axillary lymph node metastasis plays an important role in the prognosis and treatment of breast cancer.The purpose of this study was to investigate the correlation between breast cancer axillary lymph node metastasis and axillary lymph node metastasis.Methods: the ultrasonographic findings of 728 axillary lymph nodes in 366 breast cancer patients were retrospectively analyzed by single factor analysis, multivariate logistic regression and receiver operating characteristic roc curve analysis.The maximal thickness of axillary lymph node cortex, the ratio of length and diameter, the ratio of skin medulla and lymph node blood flow were examined, and the correlation between the maximum thickness of axillary lymph node cortex, the ratio of skin medulla and lymph node blood flow and the pathological axillary lymph node metastasis was studied.Results: according to univariate analysis, the maximal thickness of axillary lymph node cortex, the ratio of length and diameter, the blood flow characteristics and the positive expression rate of p53 in breast cancer were related to lymph node metastasis (P 0.05).According to multivariate analysis and ROC analysis, the maximum thickness of axillary lymph node cortex is the best index to determine axillary lymph node metastasis.Conclusion: the sonographic findings of axillary lymph nodes combined with immunohistochemical evaluation of axillary lymph node metastasis in breast cancer have important value in the selection of clinical diagnosis and treatment of breast cancer.
【作者单位】：哈尔滨医科大学附属肿瘤医院超声科;
【分类号】：R737.9;R445.1

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