强迫症患者症状严重程度与脑功能活动的关系

发布时间：2018-04-10 13:52

本文选题：强迫症 + 症状严重程度　；参考：《郑州大学学报(医学版)》2017年03期

【摘要】：目的:探讨强迫症患者的症状严重程度与其静息状态时脑功能活动的关系。方法:选取首次发作未服药的强迫症患者26例,进行静息态功能磁共振扫描。使用SPM8、DPARSFA和REST软件处理磁共振数据,以年龄作为协变量,采用Pearson相关分析探讨患者强迫症状严重程度与其全脑局部一致性(ReHo)的相关关系。结果:强迫症患者的症状严重程度与其全脑ReHo值呈正相关的脑区为:双侧额下回、双侧额中回、右侧中央前回、左侧额上回、左侧颞中回、右侧颞上回。强迫症患者的症状严重程度与其全脑ReHo值呈负相关的脑区为:双侧尾状核、左侧丘脑、双侧扣带回、左侧楔前叶。结论:额叶皮质-纹状体-丘脑-皮质环路的功能活动失衡的趋势及环路外的其他脑区如颞叶和楔前叶的功能紊乱与强迫症的发生发展密切相关。
[Abstract]:Objective: to investigate the relationship between the severity of symptoms and brain function in patients with obsessive-compulsive disorder (OCD).Methods: 26 patients with obsessive-compulsive disorder (OCD) who had not taken drugs for the first time were examined by resting functional magnetic resonance imaging (fMRI).The magnetic resonance data were processed by SPM8 DPARSFA and REST software. Age was used as a covariable and Pearson correlation analysis was used to investigate the correlation between the severity of obsessive-compulsive symptoms and the local consistency of the whole brain.Results: there was positive correlation between the severity of OCD and ReHo in the whole brain: bilateral inferior frontal gyrus, bilateral middle frontal gyrus, right precentral gyrus, left superior frontal gyrus, left middle temporal gyrus and right superior temporal gyrus.In patients with obsessive-compulsive disorder, the severity of symptoms was negatively correlated with the ReHo value of the whole brain: bilateral caudate nucleus, left thalamus, bilateral cingulate gyrus and left precuneal lobe.Conclusion: the imbalance of the functional activities of the frontal cortex striatum thalamus-cortical loop and other brain areas outside the loop such as temporal lobe and prewedge lobe are closely related to the occurrence and development of obsessive-compulsive disorder.
【作者单位】：郑州大学第一附属医院精神医学科;郑州大学第一附属医院磁共振科;中国科学院自动化研究所脑网络组研究中心;
【基金】：河南省科技重大攻关项目142102310512 西部精神医学协会科研基金资助Wcpafund-201608
【分类号】：R445.2;R749.7

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