弥散峰度成像对高级别脑胶质瘤和单发脑转移瘤的鉴别价值研究

发布时间：2018-04-10 14:44

本文选题：高级别胶质瘤 + 单发脑转移瘤　；参考：《临床放射学杂志》2016年06期

【摘要】：目的探讨弥散峰度成像(DKI)对鉴别高级别脑胶质瘤和单发脑转移瘤的临床应用价值。方法搜集经病理或临床证实的33例脑肿瘤患者纳入研究,其中高级别胶质瘤18例,单发脑转移瘤15例,分别行常规磁共振平扫、DKI及常规增强扫描。经后处理分别得到DKI相关参量图,分别测量在肿瘤实性部分、瘤周水肿区域的各参数值。采用两样本t检验,分析高级别脑胶质瘤与单发脑转移瘤实质部分和瘤周水肿区域的各相对参数值平均弥散峰度(MK)、部分各向异性(FA)、平均扩散系数(MD),分析差异有无统计学意义。结果在肿瘤实质部分,高级别脑胶质瘤和单发脑转移瘤MK、FA、MD各相对参数值比较,差异均无统计学意义(P值分别为0.529、0.645、0.84)。在瘤周水肿区域,高级别胶质瘤和单发脑转移瘤MK、FA、MD各相对参数值比较,差异均有统计学意义(P值分别为0.002、0.003、0.04)。结论 (1)DKI各相对参数MK、FA、MD在肿瘤实质部分对鉴别高级别脑胶质瘤和单发脑转移瘤没有明显价值。(2)DKI各相对参数MK、FA、MD在瘤周水肿区域对高级别脑胶质瘤和单发脑转移瘤有鉴别诊断价值。
[Abstract]:Objective to evaluate the clinical value of DKI in differentiating high grade gliomas from single brain metastases.Methods Thirty-three patients with brain tumors confirmed by pathology or clinic were included in the study, including 18 cases of high grade gliomas and 15 cases of single brain metastases.The parameters of DKI were measured in the solid part of the tumor and the region of edema around the tumor.Two samples t test were used to analyze the mean diffusive kurtosis, partial anisotropy and average diffusion coefficient (MDN) in the parenchymal part of high grade glioma and single brain metastases and the surrounding edema area. The difference was statistically significant.Results in the parenchymal part of the tumor, there was no significant difference in the relative parameters of MKF and MD between high grade glioma and single brain metastases (P = 0. 529, 0. 645) and 0. 84% (P = 0. 529) respectively.In the peritumoral edema area, the relative parameters of high grade gliomas and single brain metastases were significantly different (P = 0.002, 0.003, P = 0.04, respectively).Conclusion there is no significant value in differentiating high-grade gliomas from single brain metastases by the relative parameters of MKF-FAMD in the tumor parenchyma. The relative parameters of MK-FAMD are valuable in differentiating high-grade gliomas from single brain metastases in the edema area around the tumor.
【作者单位】：徐州医学院附属医院影像科;
【分类号】：R445.2;R739.41

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