Geant4不同物理模型对放疗质子束模拟的影响

发布时间：2018-04-10 17:22

本文选题：物理模型 + 质子放疗　；参考：《原子能科学技术》2015年07期

【摘要】：Monte Carlo方法常用于质子束剂量模拟以优化质子束临床治疗,合适的物理模型选择关系到Monte Carlo模拟结果的可靠性及模拟效率。本工作选取9个可用于质子模拟的Geant4物理模型,计算比较了质子束在多种介质中的剂量及次级粒子产额。结果表明:标准电磁物理模型、低能电磁Penelope模型和Livermore模型虽在模拟质子整体剂量分布上可接受,但在微观上缺失重粒子生成。参数化驱动模型LHEP的模拟时间最短,但与QGSP相同,均不能产生复杂重离子。QGSP_BIC_EMY模型较其他模型明显低估Bragg峰-入口剂量比和绝对剂量。QGSP_BERT模型、QGSP_BIC模型和FTFP_BERT模型较适合放疗质子束模拟。
[Abstract]:Monte Carlo method is often used to simulate the dose of proton beam in order to optimize the clinical treatment of proton beam. The selection of suitable physical model is related to the reliability and efficiency of the simulation results of Monte Carlo.In this work, nine Geant4 physical models can be used to simulate proton. The dose of proton beam in various media and the yield of secondary particles are calculated and compared.The results show that the standard electromagnetic physical model, the low-energy electromagnetic Penelope model and the Livermore model are acceptable in simulating the whole dose distribution of proton, but the formation of heavy particles is absent in microcosmic.The simulation time of parameterized driving model LHEP is the shortest, but it is the same as that of QGSP.Compared with other models, the Bragg peak to inlet dose ratio and the absolute dose. QGSPBERT model could not produce complex heavy ions. The QGSPStackBIC model and the FTFP_BERT model were more suitable for radiotherapy proton beam simulation than other models.
【作者单位】：合肥工业大学电子科学与应用物理学院;蚌埠医学院公共课程部;中国科学院核能安全技术研究所;
【基金】：中国科学院战略性先导科技专项资助项目(XDA03040000) 合肥工业大学科学发展研究基金资助项目(2013HGXJ0193,J2014HGXJ0093) 合肥工业大学自主创新项目资助(2012HGZY0007)
【分类号】：R730.55

【共引文献】