正常人静息状态功能磁共振锥体外系相关的功能连接性研究

发布时间：2018-04-11 01:04

本文选题：正常 + 人静　；参考：《扬州大学》2014年硕士论文

【摘要】：第一部分正常人中脑红核与黑质静息状态功能网络连接研究目的运用静息态功能磁共振成像(resting-state fMRI)技术,分析感兴趣区与全脑其它脑区间的功能连接,探讨正常人在静息状态下,中脑的红核及黑质的功能连接网络。方法正常健康受试者20人,招募自扬州大学医学院及扬州市城区,受试者接受静息状态下fMRI扫描和磁敏感成像,提取fMRI数据的低频波动信号,以红核和黑质作为种子区,通过时程相关分析方法获取红核和黑质的网络结构。使用Rest软件包进行组水平单样本t检验,阈值设为经Alphasim校正的p0.001,激活像素范围42。结果红核的功能连接网络构成脑区包含：前扣带回背侧、缘上回、丘脑腹内、腹外侧核、苍白球、背侧丘脑、海马头部、黑质、脑桥、小脑齿状核；黑质的功能连接网络构成脑区包含：缘上回、辅助运动区、苍白球、海马、岛叶、红核、脑桥、小脑齿状核；左右两侧红核、黑质网络构造分别呈左右基本对称分布。红核与黑质的功能网络尽管大部重叠,但是还是存在一定的差别,红核呈现了与纹状体及丘脑更广泛的功能连接。结论中脑红核、黑质的功能网络结构主要表现为与锥体外系核团间的紧密联系,与其生理功能是一致的；除了与皮层下结构有广泛的功能连接,红核、黑质还与少数大脑皮层的脑区呈现功能协同；我们的研究表明磁共振功能连接成像是探索锥体外系功能图谱的潜在的有力工具。第二部分正常人静息状态下小脑齿状核的功能网络连接研究目的运用静息态功能磁共振成像(resting-state fMRI)技术,分析感兴趣区与全脑其它脑区间的功能连接,探讨正常人在静息状态下,小脑齿状核的功能连接网络。方法正常健康受试者20人,招募自扬州大学医学院及扬州市城区,受试者接受静息状态fMRI扫描和磁敏感成像,通过时程相关分析方法检测fMRI数据的低频波动信号,获取以小脑左右侧齿状核作为种子区的网络结构,使用Rest软件包进行组水平单样本t检验,阈值设为经Alphasim校正的p0.001,激活像素范围42。结果左侧齿状核的功能连接网络构成脑区主要包含：两侧小脑半球、小脑扁桃体、小脑蚓部、对侧齿状核、脑桥、中脑(红核、黑质)、背侧丘脑、豆状核、苍白球、屏状核、岛叶；右侧齿状核的功能连接网络构成脑区主要包含：两侧小脑半球、小脑扁桃体、对侧齿状核、小脑蚓部、脑桥；左右两侧齿状核网络构造分别呈左右基本对称分布。结论齿状核的功能网络构造主要包含了小脑、脑干、丘脑及一些大脑皮层下核团,其功能网络呈现了锥体外系结构的紧密联系,反映了功能网络与解剖网络的一致性。齿状核的网络分析可以反映锥体外系的功能连接情况。
[Abstract]:Part I study on the connections between the red nucleus of the midbrain and the resting state of the substantia nigra in normal subjectsObjective to analyze the functional connections between the region of interest and other brain regions of the whole brain using resting functional magnetic resonance imaging (fMRI) technique, and to explore the functional connections between the red nucleus and the substantia nigra of the midbrain in normal subjects.Methods Twenty healthy subjects were recruited from Yangzhou University School of Medicine and Yangzhou City. The subjects received fMRI scanning and magnetic sensitivity imaging under resting state, and extracted the low frequency wave signals from fMRI data. The red nucleus and substantia nigra were used as seed regions.The network structure of red nucleus and substantia nigra was obtained by time history correlation analysis.Rest software package was used to test the group level single sample, the threshold value was set to p0.001 corrected by Alphasim, and the active pixel range was 42.Results the functional connective network of the red nucleus consisted of the dorsal cingulate gyrus, superior marginal gyrus, ventral thalamus, ventrolateral nucleus, globus pallidus, dorsal thalamus, hippocampal head, substantia nigra, pons and dentate nucleus of cerebellum.The functional junction network of the substantia nigra consists of superior marginal gyrus, auxiliary motor area, globus pallidus, hippocampus, island lobe, red nucleus, pons and cerebellar dentate nucleus.Although most of the functional networks of the red nucleus and the substantia nigra overlap, there are some differences between the red nucleus and the striatum and thalamus.Conclusion the functional network structure of the mesencephalic red nucleus and substantia nigra is mainly related to the outer pyramidal nucleus and is consistent with its physiological function, except for the extensive functional connection with the subcortical structure.The substantia nigra is also present in synergy with a few areas of the cerebral cortex; our research suggests that magnetic resonance imaging is a potentially powerful tool for exploring the functional map of extrapyramidal systems.Part II functional network connections of the dentate nucleus of the cerebellum in normal subjects at restAim to analyze the functional connections between the region of interest and other brain regions of the whole brain using resting functional magnetic resonance imaging (fMRI) technique, and to explore the functional connectivity network of the dentate nucleus of the cerebellum in the rest state of normal persons.Methods Twenty healthy subjects were recruited from Yangzhou University School of Medicine and Yangzhou City. The subjects received resting fMRI scan and magnetic sensitivity imaging. The low frequency wave signals of fMRI data were detected by time-history correlation analysis.The network structure with the left and right dentate nucleus of cerebellum as seed region was obtained. The threshold value was set to p0.001 corrected by Alphasim and the activation pixel range was 42. 2 by using Rest software package to perform a single sample t-test at the level of group level.Results the functional connective network of the left dentate nucleus consisted of bilateral cerebellar hemisphere, cerebellar tonsil, cerebellar vermis, contralateral dentate nucleus, pons, midbrain (red nucleus, substantia nigra, dorsal thalamus, lenticular nucleus, globus pallidus, platelike nucleus).The functional connective network of the right dentate nucleus consists of the bilateral cerebellar hemisphere, the cerebellar tonsil, the contralateral dentate nucleus, the cerebellar vermis, and the pons.Conclusion the functional network of dentate nucleus mainly consists of cerebellum, brainstem, thalamus and some subcortical nuclei. Its functional network is closely related to the structure of extrapyramidal system, which reflects the consistency between functional network and anatomical network.The network analysis of dentate nucleus can reflect the functional connection of extrapyramidal system.
【学位授予单位】：扬州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2;R742

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