动脉自旋标记与动态磁敏感对比增强灌注成像在急性脑梗死诊断中的对比研究

发布时间：2018-04-12 11:15

本文选题：急性脑梗死 + 动脉自旋标记　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:对比分析磁共振动脉自旋标记(arterial spin labeling,ASL)与动态磁敏感对比增强灌注成像(dynamic susceptibility contrast perfusion weighted imaging,DSC-PWI)在急性脑梗死中的应用价值。方法:对发病时间在72小时内的30例急性脑梗死患者,采用T1WI、T2WI、DWI、FLAIR、扩散加权成像(DWI)、MRA、ASL及DSC-PWI检查,对比观察ASL与DSC的在急性脑梗死中的灌注表现,采用对称性检(Bowker检验)分析DSC-PWI各参数分别与ASL-CBF的相关性。结果:30例行磁共振检查的急性脑梗死患者,ASL灌注结果显示低灌注24例,正常灌注3例,高灌注3例;DSC灌注结果显示低灌注23例,正常灌注5例,高灌注2例;ASL与DSC低灌注结果一致23例,高灌注结果一致2例,正常灌注结果一致3例,低灌注结果一致率为76.6%。ASL灌注结果与DSC-PWI中CBF、CBV相比,具有统计学差异(P0.05),ASL与DSC-PWI中MTT、TTP相比,无明显统计学差异(P0.05),与MTT、TTP的加权Kappa值分别为0.569、0.633,ASL与DSC-TTP具有较好一致性。结论:在急性脑梗死诊断中,ASL技术灌注结果与DSC技术相比有较好一致性,具有无创性且对低灌注的检测敏感性较高。
[Abstract]:Objective: to compare and analyze the value of dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI) with magnetic resonance arteriolar spin labeling (ASL) and dynamic magnetic sensitivity contrast enhanced perfusion imaging (DSC-PWI) in acute cerebral infarction.Methods: 30 patients with acute cerebral infarction within 72 hours were examined with T1WII T2WIT2WIFLAIR.DWIIMA MRAASL and DSC-PWI were examined by diffusion weighted imaging. The perfusion manifestations of ASL and DSC in acute cerebral infarction were compared and observed.The correlation between the parameters of DSC-PWI and ASL-CBF was analyzed by using the symmetry Bowker test.Results the results of ASL perfusion in 30 cases of acute cerebral infarction showed that 24 cases had low perfusion, 3 cases had normal perfusion, 3 cases had high perfusion, 23 cases had low perfusion and 5 cases had normal perfusion.The results of hyperperfusion were consistent with those of DSC in 23 cases, hyperperfusion in 2 cases and normal perfusion in 3 cases. The results of low perfusion were as follows: compared with DSC-PWI in DSC-PWI, there was statistical difference between 76.6%.ASL and DSC-PWI.There was no significant statistical difference (P 0.05). The weighted Kappa values of TTP and MTT were 0. 569 and 0. 633A, respectively. There was a good agreement between ASL and DSC-TTP.Conclusion: in the diagnosis of acute cerebral infarction, the perfusion results of ASL technique are consistent with those of DSC technique, and they are noninvasive and sensitive to low perfusion.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R743.33

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