三乙醇胺乳膏防治头颈部肿瘤放射性皮炎的临床观察

发布时间：2018-04-14 10:10

本文选题：三乙醇胺乳膏 + 头颈部肿瘤　；参考：《中国药房》2015年14期

【摘要】：目的:观察三乙醇胺乳膏防治头颈部肿瘤患者放射性皮炎的疗效。方法:将我院2010年1月-2013年6月收治的84例接受放疗的头颈部肿瘤患者按随机数字表法分为用药组44例和对照组40例。用药组在放疗开始时即给予辐射野皮肤三乙醇胺乳膏涂抹,对照组只进行常规皮肤护理指导。观察两组患者放射性皮炎发生的程度、时间、累积辐射剂量与皮损愈合时间。结果:两组患者放射性皮炎发生率均为100%,但用药组出现皮肤反应较对照组晚,差异具有统计学意义(P0.05);用药组发生Ⅰ~Ⅲ级放射性皮炎的平均累积辐射剂量均低于对照组,差异具有统计学意义(P0.05);用药组Ⅰ~Ⅲ级放射性皮炎的发生率分别为54.5%、31.8%、11.4%,对照组分别为42.5%、37.5%、15.0%,组间比较差异具有统计学意义(P0.05);用药组皮损平均愈合时间明显低于对照组,组间比较差异具有统计学意义(P0.01)。结论:三乙醇胺乳膏能有效预防和减轻头颈部肿瘤治疗过程中的放射性皮肤损伤,缩短皮损愈合时间。
[Abstract]:Objective: To observe the curative effect of prevention and treatment of head and neck cancer patients with Trolamine Cream radioactive dermatitis. Methods: in our hospital in January 2010 -2013 year in June 84 cases received radiotherapy for head and neck cancer patients were randomly divided into treatment group 44 cases and 40 cases in the control group. The treatment group before radiotherapy is given when radiation skin smear Trolamine Cream the control group, only routine skin care guide. Two groups were observed in patients with radioactive dermatitis, time, cumulative radiation dose and the healing time. Results: the two groups of patients with radioactive dermatitis incidence was 100%, but appeared in the treatment group than the control group in late skin reaction, the difference was statistically significant (P0.05); the average cumulative radiation dose medication group I ~ III radioepidermitis was lower than the control group, the difference was statistically significant (P0.05); the incidence rate of group I ~ III radioactive dermatitis Were 54.5%, 31.8%, 11.4%, the control group were 42.5%, 37.5%, 15%, the difference was statistically significant (P0.05); the average healing time of treatment group lesions was significantly lower than the control group, the difference was statistically significant (P0.01). Conclusion: Trolamine Cream can effectively prevent and reduce the radiation injury of skin of head and neck in the process of cancer treatment, shorten the healing time.

【作者单位】：东南大学附属第二医院药剂科;东南大学附属第二医院放疗科;
【基金】：南京市科技发展计划项目(No.201303014)
【分类号】：R730.55

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