天津地区低剂量CT肺癌基线筛查与随访的初步临床分析

发布时间：2018-04-18 07:41

  本文选题：肺癌筛查 + 低剂量CT　； 参考：《中国肿瘤临床》2017年20期

【摘要】：目的:探讨低剂量CT(low-dose computed tomography,LDCT)基线与随访扫描的筛查效果,并对基线检出与随访新发结节及其他胸部病变进行临床分析。方法:研究纳入2014年2月至2016年6月参与天津市肿瘤医院放射科肺癌筛查试验的650例被试者,并侧重对其中完成随访扫描的548例被试者进行分析。研究者记录基线筛查检出结节以及其他病变,将其与随访扫描的LDCT图像相比较,记录其进展情况。结果:LDCT基线筛查有101例被试者为阳性,阳性率为18.4%。共检出6例肺癌结节,肺癌检出率0.92%(6/650)。女性非吸烟者的肺癌检出率1.59%(2/126)高于男性吸烟者1.04%(4/383),差异无统计学意义(P=0.624)。随访扫描检出19例新发结节阳性被试者,新发结节阳性率为3.5%(19/548)。以三维水平对结节增大或减小的判定比例均高于二维水平。结论:LDCT肺癌筛查对早期肺癌的筛查效能显著,对女性非吸烟者行LDCT肺癌筛查同样意义重大。计算机辅助诊断系统(CAD)三维容积测量技术,相较于二维直径的评估更能对随访间隔内结节的进展做出评价。
[Abstract]:Objective: to investigate the screening effect of baseline and follow-up scans of low dose CT(low-dose computed tomographyosis (LDCT), and to analyze the clinical results of baseline detection and follow-up of new nodules and other chest lesions.Methods: from February 2014 to June 2016, 650 patients were enrolled in the lung cancer screening test in radiology department of Tianjin Cancer Hospital, and 548 of them who completed follow-up scan were analyzed.The researchers recorded the nodules and other lesions detected by baseline screening and compared them with LDCT images from follow-up scans to record their progress.Results 101 subjects were positive in the 10 ~ (th)% LDCT baseline screening, and the positive rate was 18.4%.A total of 6 cases of lung cancer nodules were detected, the detection rate of lung cancer was 0.92%.The detection rate of lung cancer in female non-smokers was 1.59 / 126) higher than that in male smokers (1.044 / 4 / 383g). The difference was not statistically significant (P 0.624).19 new nodule positive subjects were detected by follow-up scan, the positive rate of new nodule was 3.5% and 19% 548%.The proportion of 3 D to nodular enlargement or decrease was higher than that of 2 D.Conclusion the LDCT lung cancer screening for female non-smokers is of great significance in early stage lung cancer screening as well as in the early stage of lung cancer screening.Computer aided diagnosis system (CAD) 3D volumetric measurement can be used to evaluate the progress of follow-up septal nodules better than that of 2D diameter.
【作者单位】： 天津医科大学肿瘤医院放射科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心;
【基金】：天津市科学技术委员会抗癌重大科技专项(编号:12ZCDZSY15500)资助~~
【分类号】：R730.44;R734.2
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本文编号：1767442