胸中上段食管癌调强放疗不同能量X线对肿瘤计划靶区PTV及危及器官的影响

发布时间：2018-04-28 08:10

本文选题：食管癌 + 调强放疗　；参考：《中国老年学杂志》2017年10期

【摘要】：目的探讨胸中上段食管癌调强放疗(IMRT)不同能量的X线对肿瘤计划靶区(PTV)及危及器官的影响。方法 96例胸中上段食管癌患者,在Pinnacle3治疗计划系统中分别采用6 MV和15 MV X线对每例患者进行调强放疗计划设计。两组IMRT优化参数和射野参数相同,分析比较不同能量X线放疗条件下患者PTV的剂量和体积分布参数、均匀性指数、适形度指数以及双肺、脊髓、心脏受照射剂量的差异。结果经不同能量X线治疗后,6 MV组与15 MV组PTV中Dmin、Dmax、Dmean、D5%、D95%、HI及CI均无显著差异(P0.05);而15 MV组肺V5、肺V20、肺V30、脊髓Dma、心脏V30、心脏Dmean、正常组织V20及正常组织V31.5等参数明显高于6 MV组(P0.05),而肺V10、肺V50、肺Dmean、心脏V40、正常组织V5、正常组织V10指标差异无统计学意义(P0.05)。结论针对胸中上段食管癌患者,采用6 MV X线进行IMRT能够有效减少放疗过程中对危及器官及正常组织的放射性损伤,降低相关并发症发生率。
[Abstract]:Objective to investigate the effect of different energy of IMRTT on PTV (tumor planning target) and organ danger in upper and middle thoracic esophageal carcinoma. Methods 96 patients with upper and middle thoracic esophageal carcinoma were treated with 6 MV and 15 MV X-ray in the Pinnacle3 treatment planning system respectively. The intensity modulated radiotherapy plan was designed for each patient. The optimal parameters and field parameters of IMRT were the same in two groups. The dose and volume distribution parameters, uniformity index, conformability index and dose of radiation to the lungs, spinal cord and heart of patients with PTV were analyzed and compared under different energy X-ray radiation conditions. Results after different energy X ray therapy, there was no significant difference in DmaxDmaxDmean D5 and D95HI and CI in PTV between 6 MV group and 15 MV group, while the parameters of lung V5, lung V20, lung V30, spinal cord Dma, heart V30, heart Dmean, normal tissue V20 and normal tissue V31.5 in 15 MV group were significantly higher than those in 6 MV group. There was no significant difference in V10, V50, Dmean, V40, V5 and V10 between the two groups. Conclusion for patients with middle and upper thoracic esophageal carcinoma, IMRT with 6 MV X ray can effectively reduce radiation damage to organs and normal tissues during radiotherapy, and reduce the incidence of related complications.
【作者单位】：遵义医学院附属医院肿瘤医院放疗区;
【分类号】：R730.55;R735.1

【相似文献】