钆特酸葡胺与钆喷酸葡胺在肝脏血管增强效能中的对比研究

发布时间：2018-04-28 17:41

本文选题：钆特酸葡胺 + 钆喷酸葡胺　；参考：《中国医学计算机成像杂志》2017年05期

【摘要】：目的:通过对比钆特酸葡胺(Gd-DOTA)与钆喷酸葡胺(Gd-DTPA)在肝脏血管中的应用,观察两种对比剂的MRI增强效能。方法:收集我院2016年11月-2017年2月期间参与肝脏血管增强受试者146例,其中Gd-DOTA组81例,男性67例,女性14例,年龄26~74岁,平均年龄52.53±10.73岁;GdDTPA组65例,男性41例,女性24例,年龄27~86岁,平均年龄52.16±10.89岁。所有受试者均在同台机器进行、应用相同序列,采用Siemens Skyra 3.0T智多星DOT技术行肝脏MRI平扫及动态增强扫描,分别测量肝脏动态增强过程中蒙片、动脉期、门脉期、延迟期各期图像的噪声及肝动脉、门静脉、腹主动脉的信号强度,计算得到信噪比、对比噪声比。并对整体图像质量与增强效果进行评分。结果:Gd-DOTA组腹主动脉在肝脏动态增强动脉期、门脉期、延迟期的SNR、CNR均高于Gd-DTPA组(P值分别为0.544、0.508;0.940、0.962;0.496、0.553),两者差异无统计学意义;Gd-DOTA组门静脉在肝脏动态增强动脉期、门脉期、延迟期的SNR、CNR值分别高于Gd-DTPA组(P值分别为0.494、0.383;0.766、0.766;0.535、0.654),两者差异无统计学意义。Gd-DOTA组肝动脉在肝脏动态增强动脉期、门脉期、延迟期的SNR、CNR值分别高于Gd-DTPA组(P值分别为0.790、0.920;0.443、0.236;0.338、0.248),但两者差异无统计学意义。两组在图像质量与增强效果评分上无明显统计学差异,P值均0.05。结论:Gd-DOTA在肝脏血管动态增强各期的信噪比、对比噪声比均非劣于Gd-DTPA。
[Abstract]:Objective: To observe the MRI enhancement effect of two contrast agents by comparing the use of gadolinium acid glucamine (Gd-DOTA) and gadolinium acid glucamine (Gd-DTPA) in the liver vessels. Methods: 146 cases of liver vascular enhancement were collected in our hospital during February November 2016, including 81 cases in group Gd-DOTA, 67 men, 14 women, age 26~74 years, average year. Age 52.53 + 10.73 years, group GdDTPA 65 cases, male 41 cases, female 24 cases, age 27~86 years, average age 52.16 + 10.89 years old, all subjects were carried out in the same machine, using the same sequence, using Siemens Skyra 3.0T wisdom star DOT technique to perform liver MRI plain scan and dynamic enhanced scan, respectively, to measure the dynamic enhancement process of the liver and the arterial phase, respectively. The noise of the images and the signal intensity of the hepatic artery, the portal vein and the abdominal aorta in the portal period, the hepatic artery, the portal vein and the abdominal aorta were calculated and compared with the noise ratio. The overall image quality and enhancement were scored. Results: the abdominal aorta in the Gd-DOTA group was higher than the group Gd-DTPA (P value) in the dynamic enhanced arterial phase of the liver, the portal phase, the delay period, and the CNR. The difference was not statistically significant in 0.544,0.508; 0.940,0.962; 0.496,0.553). The portal vein in group Gd-DOTA was significantly higher than that in group Gd-DTPA (P value was 0.494,0.383; 0.766,0.766; 0.535,0.654) in the dynamic enhanced arterial phase of the liver, portal vein, and delayed phase (P value respectively), and there was no significant difference between the two groups of the hepatic artery in the liver. The SNR and CNR values of the strong artery, portal and delay period were higher than that of the Gd-DTPA group (P value 0.790,0.920; 0.443,0.236; 0.338,0.248), but there was no significant difference between the two groups. There was no significant difference between the two groups in the image quality and the enhancement effect score. The P values were all 0.05. knots: Gd-DOTA in the dynamic enhancement of the liver blood vessels. The ratio of noise to noise is not inferior to Gd-DTPA.

【作者单位】：郑州大学第一附属医院磁共振科;华中科技大学同济医学院附属同济医院;
【分类号】：R445.2;R575

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