DTI在巨细胞病毒感染所致感音性耳聋患儿中的应用

发布时间：2018-04-29 03:39

本文选题：巨细胞病毒 + 耳聋　；参考：《中国医学影像技术》2017年10期

【摘要】：目的探讨磁共振扩散张量成像(DTI)技术在巨细胞病毒感染(CMV)所致感音性耳聋(SNHL)患儿听觉通路中的应用价值。方法选取CMV感染所致SNHL的患儿31例,其中双侧听力受损(BPHL)组13例、单侧听力受损(UPHL)组18例[分为听力受损侧(lpsi亚组)和未受损侧(con亚组)];无听力损伤的患儿36例(对照组)。采用DTI技术获得各组双侧下丘和外侧丘系各向异性分数(FA)、平均扩散率(MD)、轴向扩散率(AD)、径向扩散率(RD),并进行统计学分析。结果与对照组相比,BPHL组双侧下丘、外侧丘系FA值减低、RD值增高(P均0.001)。与con亚组相比,lpsi亚组FA值减低、RD值增高(P均0.001)。与对照组比较,lpsi亚组双侧下丘和外侧丘系的FA值减低,双侧下丘RD值增高(P均0.001);与con亚组比较,BPHL组外侧丘系的FA值减低、RD值增高,且双侧下丘的RD值增高(P均0.001)。双侧下丘FA值与听觉阈值呈负相关(r=-0.966,P0.001)。IC和LL区的MD和AD值差异均无统计学意义(P均0.05)。结论 CMV感染所致SNHL患儿的听觉通路脑白质发生了明显改变,提示脑白质髓鞘脱失或髓鞘发育不良。
[Abstract]:Objective to investigate the value of magnetic resonance diffusion imaging (DTI) technique in auditory pathway in children with sensorineural deafness caused by cytomegalovirus (CMV) infection. Methods Thirty one children with SNHL caused by CMV infection, including 13 patients with bilateral hearing impairment, 18 patients with unilateral hearing impairment and 18 patients with unilateral hearing impairment, were divided into two groups: the hearing loss group (Lpsi subgroup) and the undamaged side group (control group), and 36 children without hearing impairment (control group). The anisotropic fractions of the inferior and lateral colliculus in each group were obtained by using DTI technique. The average diffusivity (MDN), axial diffusivity (ADN) and radial diffusivity (RDV) were measured and analyzed statistically. Results compared with the control group, the FA value of the lateral colliculus decreased and the Rd value increased in the BPHL group (P 0.001). Compared with the con subgroup, the FA value of the con subgroup decreased and the Rd value increased (P < 0. 001). Compared with the control group, the FA value of bilateral inferior colliculus and lateral colliculus was decreased, the Rd value of bilateral inferior colliculus was increased (P 0.001), the FA value of lateral colliculus in con subgroup was lower than that of control group, and the Rd value of bilateral inferior colliculus was higher than that of con subgroup (P = 0.001). There was a negative correlation between FA value of bilateral inferior colliculus and auditory threshold. There was no significant difference in MD and AD between the two regions (P < 0.05). Conclusion the auditory pathway of white matter in children with SNHL caused by CMV infection is obviously changed, indicating demyelination of white matter or maldevelopment of myelin sheath.
【作者单位】：湖南省儿童医院放射科;
【分类号】：R445.2;R764.43

【相似文献】