体素内不相干运动成像与弥散张量成像在梗阻性肾病的应用

发布时间：2018-04-29 08:08

本文选题：梗阻性肾病 + 体素内不相干运动成像　；参考：《暨南大学》2014年硕士论文

【摘要】：目的：探讨体素内不相干运动成像与弥散张量成像在梗阻性肾病中的应用价值。材料与方法：40只健康SD大鼠。32只行左侧输尿管完全梗阻制模，8只行假手术。术前均行MRI扫描，术后于不同时间点再次扫描，一批扫描手术组8只，假手术组2只，扫描后处死送病检。扫描序列包括：定位像，T2WI横断位、冠位，IVIM冠位，DTI冠位。分别对IVIM和DTI成像进行后处理，测量IVIM参数值(标准ADC、D、D*、f)和DTI各参数值(ADC、FA)，并重建DTI纤维示踪图。采用单因素方差分析比较不同时间点及皮髓质之间的参数值，并与病理结果做Pearson相关分析。结果：纤维示踪图：梗阻肾纤维束稀疏、杂乱。肾脏皮质、外髓、内髓的标准ADC、D、f、ADC及FA均随积水时间延长而递减，与α-SMA表达和肾小管间质病变分级均呈负性相关（r＜0，P=0.000）。而D*在髓质中变化不明显，仅皮质与α-SMA表达和肾小管间质病变分级呈负相关（r＜0，P＜0.05）。在皮质与外髓、内髓三者的比较中，标准ADC、D、f、ADC均表现为皮质＞外髓＞内髓，FA表现为皮质＜外髓＜内髓，D*皮髓质间无统计学差异（P＞0.05）。结论：梗阻性肾病IVIM及DTI成像不仅可以反映肾间质纤维化程度，准确评价肾功能，还有助于了解肾血流灌注、水代谢、超微结构方面的信息。
[Abstract]:Objective: to evaluate the value of voxel incoherent motion imaging and diffusive Zhang Liang imaging in obstructive nephropathy. Materials and methods: 40 healthy SD rats and 32 healthy SD rats were made model of complete obstruction of left ureter and 8 rats underwent sham-operation. MRI scan was performed before operation and re-scanned at different time points after operation. 8 rats in one group and 2 rats in sham operation group were sacrificed for examination after scanning. The scanning sequence included T _ 2 WI transection and IVIM coronal position on T _ 2 WI and DTI coronal position on IVIM. The IVIM and DTI images were post-processed, and the parameters of IVIM and DTI were measured, and the DTI fiber tracer map was reconstructed. Single factor analysis of variance (ANOVA) was used to compare the parameter values between different time points and skin medulla, and Pearson correlation analysis was made with pathological results. Results: the fibrous tracer diagram showed that the fibrous bundles of the obstructed kidney were sparse and disorderly. The standard ADC and FA of renal cortex, extramedullary and inner medulla decreased with the prolongation of hydronephrosis time, and were negatively correlated with 伪 -SMA expression and renal tubulointerstitial lesion grade (P < 0. 000). However, there was no significant change of D * in medulla, only cortical and 伪 -SMA expression and renal tubulointerstitial lesion grade were negatively correlated (r < 0. 05, P < 0. 05). In the comparison of cortical and extramedullary and inner medullary, there was no significant difference in standard ADC between cortex and extramedullary medullary (P > 0.05), but there was no significant difference in FA between cortical and outer medullary and intramedullary medullary D* (P > 0.05). Conclusion: IVIM and DTI imaging of obstructive nephropathy can not only reflect the degree of renal interstitial fibrosis and evaluate renal function accurately, but also help to understand the information of renal blood flow perfusion, water metabolism and ultrastructure.
【学位授予单位】：暨南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R692;R445.2

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