超声造影定量分析评价结直肠癌肝转移化疗的早期疗效

发布时间：2018-05-03 13:52

本文选题：结直肠肿瘤 + 肿瘤转移　；参考：《中国普通外科杂志》2015年07期

【摘要】：目的:探讨超声造影(CEUS)定量分析在结直肠癌肝转移辅以贝伐单抗联合细胞毒性化疗及仅细胞毒性化疗早期疗效评价中的应用价值。方法:将28例结直肠癌肝转移患者分成贝伐单抗联合mFOLFOX6治疗组与mFOLFOX6治疗组,每组各14例。于第1~4次化疗前1d行常规超声及CEUS,采用动态造影定量分析软件,记录患者肝脏病灶的各项定量参数,根据实体瘤疗效评价标准(RECIST)最终结果,分别比较两治疗组中有效患者与无效患者第1次化疗前1d与第2次化疗前1d病灶定量参数变化百分数的差异。结果:贝伐单抗联合mFOLFOX6治疗组有效患者与无效患者病灶定量参数峰值强度(PI)变化百分数差异有统计学意义(P=0.03),余参数差异无统计学意义(均P0.05);mFOLFOX6治疗组有效患者与无效患者病灶各参数变化百分数比较差异均无统计学意义(均P0.05)。结论:CEUS定量参数P1对于结直肠癌肝转移贝伐单抗联合细胞毒性化疗早期疗效评价有一定应用价值。
[Abstract]:Objective: to evaluate the value of quantitative analysis of contrast-enhanced echocardiography (CEUSS) in evaluating the early efficacy of combined use of bevacizumab and cytotoxic chemotherapy in the treatment of colorectal cancer liver metastasis. Methods: Twenty-eight patients with liver metastasis from colorectal cancer were divided into bevacizumab combined with mFOLFOX6 group and mFOLFOX6 group with 14 cases in each group. Routine ultrasound and CEUSwere performed 1 day before the first four times of chemotherapy. The quantitative parameters of liver lesions were recorded by dynamic quantitative analysis software, and the final results were evaluated according to the criteria for evaluating the curative effect of solid tumors. The difference of quantitative parameters between effective and ineffective patients was compared between the two groups 1 day before the first chemotherapy and 1 day before the second chemotherapy. Results: there was significant difference in the percentage change of peak intensity of lesion quantitative parameters between effective and ineffective patients in bevacizumab combined with mFOLFOX6 treatment group. There was no significant difference in the remaining parameters (all P0.05MFOLFOX6 treatment group and no P0.05% FOLFOX6 group). There was no significant difference in the percentage change of each parameter between the two groups (all P 0.05). Conclusion\\\
【作者单位】：中南大学湘雅医院超声影像科;
【基金】：湖南省科学技术厅科技计划资助项目(08SK3099)
【分类号】：R735.34;R445.1

【共引文献】