超声评价三阴性乳腺癌新辅助化疗疗效的价值

发布时间：2018-05-05 04:28

本文选题：三阴性乳腺癌 + 新辅助化疗　；参考：《中国超声医学杂志》2015年12期

【摘要】：目的分析三阴性乳腺癌新辅助化疗(NAC)前后的声像图变化,探讨高频超声对NAC疗效的评估价值。方法回顾性分析53例三阴性乳腺癌患者NAC前后病灶的大小、血流和硬度改变,并与病理对照评估。结果 NAC后超声检查9例病灶消失,其灵敏度、特异度、准确率分别为87.5%、65%、81.1%;以残余灶的最大径线、血流等级、弹性评分变化作为NAC后的评效指标,评估化疗有效的准确率分别为79.2%、84.9%、94.3%。灵敏度分别为95.2%、95.6%、97.9%。阳性预测值为95.2%、95.6%、97.9%。一致性检验Kappa值分别为0.53、0.75、0.81。结论超声对三阴性乳腺癌NAC疗效有重要评估价值,NAC后以超声弹性评分、血流等级为评效指标评估残余灶的诊断符合率、灵敏度高于以最大径线为评效指标评估残余灶,与病理组织学评估化疗的有效性具有较高的一致性。
[Abstract]:Objective to analyze the changes of sonogram before and after neoadjuvant chemotherapy in triple negative breast cancer and to evaluate the effect of high frequency ultrasound on NAC. Methods the changes of lesion size, blood flow and hardness in 53 patients with triple negative breast cancer before and after NAC were analyzed retrospectively. Results after NAC, the lesions disappeared in 9 cases, their sensitivity, specificity and accuracy were 87.5% and 65%, respectively. The maximum diameter, blood flow grade and elastic score of the residual focus were taken as the evaluation indexes after NAC, and the accuracy of evaluating the effectiveness of chemotherapy was 79.2% 84.9% and 94.3% respectively. The sensitivity was 95.2 and 95.6, respectively. The positive predictive value was 95. 2 and 95. 6%. The Kappa of conformance test was 0. 53 卤0. 75 and 0. 81 respectively. Conclusion Ultrasound has an important value in evaluating the efficacy of NAC in three-negative breast cancer. The diagnostic coincidence rate of residual foci is evaluated by ultrasound elastic score and blood flow grade, and the sensitivity is higher than that of the maximum diameter. It is consistent with histopathological evaluation of the efficacy of chemotherapy.
【作者单位】：广东省人民医院(广东省医学科学院)超声科;
【分类号】：R737.9;R445.1

【参考文献】