腺苷负荷BOLD-fMRI诊断冠心病的Meta分析

发布时间：2018-05-08 12:33

本文选题：磁共振成像 + 腺苷　；参考：《放射学实践》2017年04期

【摘要】：目的:采用Meta分析评估腺苷负荷血氧水平依赖功能磁共振(BOLD-fMRI)对冠心病的诊断价值。方法:检索2000年1月-2016年8月国内外6个数据库(Pubmed、Cochrane图书馆、Embase、CNKI相关期刊论文及外文生物医学文献数据库和万方数据知识资源系统)中关于腺苷负荷BOLD-fMRI诊断冠心病的中英文文献,分别使用Cochrane协作网QUADAS-1、Review Manager 5.3QUADAS-2对纳入文献进行质量评估,采用Meta-disc version 1.4软件进行Meta分析,获得BOLD-fMRI诊断冠心病的总体敏感度(SEN)、特异度(SPE)和诊断比值比(DOR),绘制工作特征曲线(ROC),计算曲线下面积(AUC)。结果:腺苷负荷BOLD-fMRI基于心肌节段(n=1738)水平诊断冠心病的总体SEN、SPE和DOR分别为0.79(95%CI:0.75~0.83)、0.73(95%CI:0.71~0.75)和11.79(95%CI:5.78~24.08),AUC为0.8504。结论:腺苷负荷BOLD-fMRI诊断冠心病的敏感性和特异性均较高,在临床上具有广阔的应用前景。
[Abstract]:Objective: to evaluate the diagnostic value of adenosine loaded oxygen level dependent functional magnetic resonance imaging (BOLD-f MRI) in coronary heart disease (CHD) by Meta analysis. Methods: from January 2000 to August 2016, we searched six databases at home and abroad, Pubmedus Cochrane Library, Embase CNKI full text Database, Foreign Biomedical Literature Database and Wanfang data knowledge Resource system, about adenosine load BOLD-fMRI diagnostic crown. Chinese and English literature on heart disease, QUADAS-1 Manager 5.3QUADAS-2 was used to evaluate the quality of the literature, and Meta-disc version 1.4 software was used to analyze Meta. The total sensitivity, specificity and diagnostic ratio of BOLD-fMRI in the diagnosis of coronary heart disease were obtained. The working characteristic curve was drawn and the area under the curve was calculated. Results: the total SENT-SPE and DOR of adenosine load BOLD-fMRI based on myocardial segment 1738 were 0.7995% CI: 0.75% 0.73 95 CI: 0.771 0.75) and 11.7995 CI: 5.78% 24.08A UC was 0.8504. Conclusion: adenosine loaded BOLD-fMRI has high sensitivity and specificity in the diagnosis of coronary heart disease.
【作者单位】：昆明医科大学第二附属医院放射科;
【基金】：国家自然科学基金(81260213) 云南省教育厅科学研究重点项目(2014Z057) 云南省中青年学术技术带头人培养项目(2015HB068)
【分类号】：R445.2;R541.4

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