放射性口腔黏膜炎早期使用羟考酮控释片与解热镇痛药止痛治疗的对照研究

发布时间：2018-05-10 22:07

  本文选题：鼻咽癌 + 放射治疗　； 参考：《广东医学》2017年17期

【摘要】：目的对比放射性黏膜炎轻度疼痛患者使用羟考酮控释片与世界卫生组织(WHO)三阶梯止痛方案的止痛效果与不良反应。方法收集放射性黏膜炎轻度疼痛患者40例的资料,随机分为观察组(羟考酮组)和对照组(三阶梯组)。在患者出现放射性黏膜炎轻度疼痛时,分别采用羟考酮控释片和解热镇痛类药物止痛治疗。对比两组间止痛效果、不良反应、营养状态的差异。结果观察组和对照组各20例患者入组。对照组和观察组疼痛评分≤3分的时间分别为(19.90±6.53)d和(21.73±6.91)d,差异无统计学意义(P=0.295)。两组患者体重均明显下降,两组间比较差异无统计学意义[(7.34±3.71)%vs(6.98±4.58)%,P=0.344]。两组的止痛药相关不良反应均不严重,观察组多于对照组。结论对于放射性口腔黏膜炎轻度疼痛患者,羟考酮止痛效果略优,差异无统计学意义,不良反应多于解热镇痛类药物,需要更好地对症处理。
[Abstract]:Objective to compare the analgesic effects and adverse reactions of patients with mild pain caused by radiation mucositis treated with hydroxycodone controlled release tablets and World Health Organization (WHO) three-step analgesic regimen. Methods 40 patients with mild pain in radiation mucositis were randomly divided into observation group (hydroxycodone group) and control group (three-step group). The patients with mild pain of radiation mucositis were treated with hydroxycodone controlled release tablets and antipyretic and analgesic drugs respectively. The difference of analgesic effect, adverse reaction and nutritional status between the two groups was compared. Results 20 patients in the observation group and 20 patients in the control group were admitted into the group. The time of pain score 鈮，

本文编号：1871108