磁共振弹性成像在家兔肝纤维化分期的实验研究

发布时间：2018-05-19 06:01

  本文选题：肝纤维化 + 肝硬化　； 参考：《临床放射学杂志》2015年02期

【摘要】：目的利用家兔肝纤维化模型评价磁共振弹性成像(MRE)在肝纤维化(HF)病理分期中的价值方法建立肝纤维化实验组(n=32)、实验补充组(n=12)、正常对照组(n=15)。对实验组及正常对照兔行常规MRI及MRE检查,测量肝实质的硬度(LS)值。HF组实验兔皮下注射50%CCl4后的第4、5、6、10周分别随机选择8只行MRI扫描。以肝脏纤维化病理组织学诊断为标准,评价第4、5、6、10周MRE与HF病理分期的相关性,并采用ROC曲线分析MRE的诊断准确性。结果不同分期HF的LS值之间存在显著差异(P0.001),随着HF分期加重,LS值增加。LS与HF分期存在明显相关性(r=0.948,P0.001)。LS区分各组别HF的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为:≥S1期93.8%、93.3%、93.6%、96.8%、87.5%;≥S2期95.8%、95.7%、95.7%、95.8%、95.7%;≥S3期93.8%、96.8%、95.8%、93.8%、98.8%;S4期100%、97.4%、97.9%、100%、88.9%。结论 MRE作为一种安全、可靠地无创性HF分期技术,可为临床诊治、纵向研究提供一种重要的补充手段。
[Abstract]:Objective to evaluate the value of magnetic resonance elastography (Mre) in the pathological staging of hepatic fibrosis in rabbits. Methods the experimental group of hepatic fibrosis was established. Routine MRI and MRE were performed in the experimental group and the normal control group. The hardness of liver parenchyma was measured. In HF group, 8 rabbits were randomly selected for MRI scanning 10 weeks after subcutaneous injection of 50l4. Based on the histopathological diagnosis of hepatic fibrosis, the correlation between MRE and HF staging was evaluated at the 10th week of the 4th 5th week, and the diagnostic accuracy of MRE was analyzed by ROC curve. Results there was significant difference in LS value among different HF stages (P 0.001). With the increase of LS value in HF stage, there was a significant correlation between LS and HF staging. The sensitivity, specificity and accuracy of HF were distinguished by 0.948% P 0.001. LS. The positive predictive value and the negative predictive value were as follows: 鈮，

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