卒中患者脑白质损伤与运动功能的相关性研究

发布时间：2018-05-23 19:17

本文选题：卒中 + 扩散张量成像　；参考：《第三军医大学学报》2016年10期

【摘要】：目的研究卒中偏瘫患者脑白质结构的损伤程度,并探讨脑白质损伤与运动功能障碍的相关性。方法对17例卒中偏瘫患者和21例健康对照进行大脑DTI数据扫描,应用TBSS方法对两组被试的部分各项异性(FA)、轴向弥散系数(λ_1)、径向弥散系数(λ23)进行统计分析;通过约翰霍普金斯白质分区图谱提取卒中患者组的感兴趣区域,并与上肢肢体运动功能评分进行相关分析。结果卒中患者在患侧皮质脊髓束、额枕下束、钩束、丘脑前辐射、上纵束、胼胝体额部和双侧胼胝体枕部的FA值显著降低(P0.005);患侧皮质脊髓束的λ_1值也显著降低(P0.05),患侧皮质脊髓束、额枕下束、钩束、丘脑前辐射、胼胝体额部以及双侧上纵束、胼胝体枕部的λ_(23)值显著升高(P0.01)。患侧皮质脊髓束的λ_1值与上肢Fugl-Meyer运动功能评分存在显著正相关(P0.05)。结论卒中患者脑白质纤维束的结构完整性有明显损伤,患侧皮质脊髓束的λ_1值可以反映卒中患者运动功能障碍的程度。
[Abstract]:Objective to study the degree of white matter structure injury in stroke hemiplegic patients and to explore the correlation between white matter injury and motor dysfunction. Methods DTI data of 17 patients with stroke hemiplegia and 21 healthy controls were scanned with TBSS method. The axial diffusion coefficient (位 _ (1) and radial diffusion coefficient (位 _ (23) of the two groups were statistically analyzed. The area of interest of stroke patients was extracted from Johns Hopkins white matter map, and the correlation analysis was carried out with the upper limb motor function score. Results the patients suffered from stroke in corticospinal tract, frontal suboccipital tract, hook bundle, anterior thalamic radiation, superior longitudinal tract, The FA value of the frontal part of corpus callosum and bilateral corpus callosum and occipital part of the corpus callosum decreased significantly (P 0.005), the 位 _ 1 value of the cortical spinal tract of the affected side also decreased P0.05, the cortical spinal tract of the affected side, the suboccipital tract, the hook tract, the anterior thalamic radiation, the frontal part of the corpus callosum and the bilateral superior longitudinal tract of corpus callosum. In the corpus callosum occipital region, the value of 位 _ T _ (23) increased significantly (P _ (0.01). There was a significant positive correlation between 位 _ 1 of corticospinal tract and Fugl-Meyer motor function score of upper limb (P 0.05). Conclusion the structural integrity of white matter fiber bundle in stroke patients is obviously damaged. The 位 _ 1 value of corticospinal tract can reflect the degree of motor dysfunction in stroke patients.
【作者单位】：第三军医大学生物医学工程系医学图像学教研室;第三军医大学西南医院放射科;第三军医大学西南医院康复科;
【基金】：国家自然科学基金面上项目(81171866) 教育部留学回国人员科研启动基金(2012) 国家重点基础研究发展计划(973计划,2014CB541602)~~
【分类号】：R445.2;R743.3

【相似文献】