磁共振DWI及DCE序列对早期强直性脊柱炎临床疗效评价的应用研究

发布时间：2018-05-24 07:32

本文选题：磁共振 + 弥散加权成像　；参考：《中国矫形外科杂志》2015年07期

【摘要】：[目的]探讨磁共振DWI、DCE序列对评价中西医结合治疗早期强直性脊柱炎疗效的应用价值。[方法]随访前期研究中的48例(男38例、女10例)确诊为早期AS并经中西医治疗的患者,通过磁共振DWI及DCE扫描,获取治疗后关节面下骨髓ADC平均值,绘制TIC曲线,计算Fenh、Senh值及达峰时间Tmax值,与前期研究所获取治疗前相应数据进行统计学分析比对。[结果]经临床治疗的患者骶髂关节面下骨髓区ADC平均值:髂骨侧为(4.34±0.55)×10-4mm2/s,骶骨侧为(3.96±0.23)×10-4mm2/s,均较治疗前减低,组间差距具有显著统计学意义。半定量指标Fenh、Senh均较对照组明显减低,Tmax高于对照组,差异具有统计学意义。骶髂关节骶、髂侧ADC值与Fenh值间呈高度正相关关系(P0.05),髂侧ADC值与Senh呈高度正相关关系(P0.05)。[结论]磁共振DWI及DCE序列可用于评价AS炎症活动程度变化,反映早期AS患者的治疗疗效,并可为临床疗效提供可靠的影像学依据。
[Abstract]:[objective] to evaluate the clinical value of DWI DCE sequence in the treatment of early ankylosing spondylitis (ankylosing spondylitis). [methods] 48 patients (38 males and 10 females) who were diagnosed as early and were treated with traditional Chinese and western medicine were studied in the early follow-up study. The mean value of ADC in bone marrow of articular surface after treatment was obtained by DWI and DCE scanning, and TIC curve was drawn. The Senh value and peak time (Tmax) were calculated and compared with the corresponding data before treatment. [results] the average value of ADC in the subarticular surface of sacroiliac bone marrow was 4.34 卤0.55 脳 10 ~ (-4) mm ~ (-2) / s in the iliac side and 3.96 卤0.23 脳 10 ~ (-4) mm ~ (2 / s) in the sacral side. The difference between the two groups was statistically significant. Compared with the control group, the semi-quantitative index Fenhn Senh was significantly lower than that of the control group, and the difference was statistically significant. In sacroiliac joint, there was a high positive correlation between ADC and Fenh in sacroiliac joint (P 0.05), and a high positive correlation between ADC (P 0.05) and Senh (P 0.05). [conclusion] MRI DWI and DCE sequences can be used to evaluate the changes of inflammatory activity of as, to reflect the therapeutic effect of early as patients, and to provide reliable imaging evidence for clinical efficacy.
【作者单位】：泰山医学院附属医院影像科;
【基金】：山东省卫生厅医药卫生科技发展计划项目(编号:2013WS0325)
【分类号】：R593.23;R445.2

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