高血压患者颈动脉内中膜厚度与脂联素的关系

发布时间：2018-05-27 22:13

本文选题：高血压 + 脂联素　；参考：《广东医学》2015年07期

【摘要】：目的探讨高血压患者颈动脉内中膜厚度(IMT)与血浆脂联素水平(APN)的变化及其关系。方法收集原发性高血压患者80例,按IMT分别为高血压内膜正常组、高血压内膜增厚组,另收集门诊体检正常者40例为对照组。检测3组的血糖(FBG)、血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);采用酶联免疫吸附法测定血浆APN水平。应用彩色多普勒超声仪测定颈动脉IMT。结果组间比较,高血压内膜正常组与内膜增厚组血浆LDL-C、TC水平均高于对照组,差异有统计学意义(P0.05),LDL-C、TC水平在高血压内膜正常组与内膜增厚组间的比较差异无统计学意义(P0.05);FBG、TG、HDLC在3组间差异无统计学意义(P0.05)。高血压内膜增厚组APN低于高血压内膜正常组[(2.36±0.27)vs(3.28±0.25)mmol/L,P0.01)]及对照组[(2.36±0.27)vs(4.25±0.22)mmol/L,P0.01)];高血压内膜正常组低于对照组(P0.05)。相关分析显示高血压患者IMT与APN(r=-0.232,P=0.028)呈负相关;与LDL-C(r=0.207,P=0.036)呈正相关;与HDL-C、TC、TG、FBG无相关性。结论高血压患者血浆APN水平降低,IMT与APN水平呈负相关,IMT增厚与低APN血症可能都与高血压的发展有关。
[Abstract]:Objective to investigate the relationship between plasma adiponectin (APN) and carotid intima-media thickness (IMT) in patients with hypertension. Methods Eighty patients with essential hypertension were divided into normal hypertensive endometrium group and hypertension intimal thickening group according to IMT. 40 normal subjects were collected as control group. The levels of APN in plasma were determined by enzyme linked immunosorbent assay (Elisa). The levels of plasma total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were measured in three groups. IMT of carotid artery was measured by color Doppler ultrasound. Results compared with the control group, the plasma LDL-CTC levels in the hypertensive intima normal group and intimal thickening group were higher than those in the control group. There was no significant difference in the level of LDL-CnTC between the normal hypertensive endometrium group and the intimal thickening group. There was no significant difference in the HDLC between the three groups. APN in hypertensive intima thickening group was lower than that in normal hypertensive endometrium group [2.36 卤0.25mmol / L P0.01] and control group (2.36 卤0.27)vs(4.25 卤0.22 mmol / L P0.01), while that in hypertensive intimal normal group was lower than that in control group (P 0.05). Correlation analysis showed that there was a negative correlation between IMT and APNNr-0.232 P0.028, a positive correlation with LDL-Cnru 0.207 P0.036), and no correlation with HDL-Cnr TCG-TGG. Conclusion there is a negative correlation between the decrease of plasma APN level and the level of APN in hypertensive patients. Both thickening of IMT and hypoglycemia may be related to the development of hypertension.
【作者单位】：海南省第三人民医院超声科;海南省第三人民医院心内科;
【基金】：海南省三亚市医疗卫生科技创新项目(编号:YW1211)
【分类号】：R544.1;R445.1

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