青年女性乳腺浸润性导管癌的动态增强MRI表现特点及其早期最大强化率及时间信号强度曲线与Ki-67的相关性研究

发布时间：2018-05-31 06:23

  本文选题：青年女性 + 乳腺癌　； 参考：《临床放射学杂志》2017年11期

【摘要】：目的回顾性分析青年女性乳腺浸润性导管癌的动态增强MRI特征,探讨早期最大强化率(EPER)及时间信号强度曲线(TIC)与Ki-67之间的相关性。方法搜集术前均行MRI动态增强扫描并经病理证实的32例青年女性乳腺浸润性导管癌患者资料,记录肿瘤的形态学及血流动力学特点,记录Ki-67的表达情况。采用Spearman相关检验对EPER及TIC与Ki-67进行相关性分析。结果 32例乳腺癌患者的病灶均位于单侧乳腺,非肿块型6例,肿块型26例。肿块型MRI表现:不规则形17例,卵圆形6例,圆形3例;边缘有毛刺或边缘不规则23例,边缘清晰3例;不均匀强化25例,均匀强化1例;非肿块型的MRI表现:弥漫分布5例,区域分布1例;不均匀强化占5例,均匀强化占1例。平扫时T_1低或等信号27例,T_1稍高或高信号5例;T_2低或等信号9例,T_2稍高或高信号23例;动态增强后的TIC类型:平台型4例,流出型28例。Ki-67表达水平为5%~80%,平均(44.38±22.50)%。EPER及TIC与生物学因子Ki-67之间的相关系数分别为-0.103、0.031(P0.05)。结论青年女性浸润性导管癌多表现为形态不规则或弥漫分布,边缘不清晰,T_1低或等信号,T_2稍高信号,增强后呈不均匀强化,TIC曲线呈流出型的MRI特征。本研究显示,EPER及TIC与生物学因子Ki-67之间无明确相关性。
[Abstract]:Objective to analyze the characteristics of dynamic enhanced MRI in young women with invasive ductal carcinoma of breast, and to explore the correlation between early maximum enhancement rate (EPERA) and time signal intensity curve (TICs) and Ki-67. Methods the data of 32 young female breast invasive ductal carcinoma patients who underwent dynamic enhanced MRI scanning before operation and confirmed by pathology were collected. The morphological and hemodynamic characteristics of the tumor and the expression of Ki-67 were recorded. Spearman correlation test was used to analyze the correlation between EPER, TIC and Ki-67. Results the lesions of 32 cases of breast cancer were located in unilateral breast, 6 cases were non-mass type and 26 cases were mass type. MRI findings of mass type were irregular in 17 cases, oval in 6 cases, round in 3 cases, brim or irregular margin in 23 cases, edge clear in 3 cases, uneven enhancement in 25 cases, homogeneous enhancement in 1 case, and diffuse distribution in 5 cases. Regional distribution was found in 1 case, heterogeneous enhancement in 5 cases and homogeneous enhancement in 1 case. 27 cases of low or iso-signal T _ 1 on plain scan 27 cases of T _ 1 slightly high or high signal 5 cases of T _ 2 low or iso-signal 9 cases of T _ 2 slightly high or high signal 23 cases; dynamic enhancement of TIC type: platform type 4 cases, The expression level of Ki-67 was 54.38 卤22.50)%.EPER, and the correlation coefficient between TIC and Ki-67 was -0.103 and 0.031, respectively. Conclusion the infiltrating ductal carcinoma in young women is characterized by irregular or diffuse distribution, low or equal signal intensity of T _ (2) on the edge of T _ (1) and slightly high signal intensity of T _ (2), and an inhomogeneous enhanced TIC curve with efflux type of MRI after enhancement. This study showed that there was no clear correlation between Eper and TIC and biological factor Ki-67.
【作者单位】： 第二军医大学附属长海医院放射介入科;第二军医大学附属长海医院放射科;
【基金】：国家临床重点专科军队建设项目资助
【分类号】：R445.2;R737.9
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本文编号：1958634