慢性脊髓损伤后脑结构重塑的磁共振成像研究

发布时间：2018-06-01 00:31

本文选题：脊髓损伤 + 创伤和损伤　；参考：《中国医学影像技术》2015年05期

【摘要】：目的联合应用基于体素的形态学(VBM)研究和扩散张量成像(DTI)探讨慢性脊髓损伤(SCI)患者全脑灰、白质变化规律。方法对20例慢性SCI患者(SCI组)和30名健康志愿者(对照组)行全脑容积及DTI扫描,分析患者全脑灰、白质结构改变及纤维束完整性的变化。结果与对照组比较,SCI组脑灰质体积减小区域主要有左侧初级运动皮层(M1)、左侧运动前区(PMA)、右侧前扣带回、右侧直回、左侧额下回、右侧颞下回、左侧枕中回及右侧楔前叶(P0.001)。白质体积减小的区域主要有:双侧辅助运动区、双侧锥体束走行区、左侧M1及胼胝体(P0.001)。FA值减小的区域主要有胼胝体干、左侧内囊前肢及左侧顶下小叶。MD值增高的区域主要为胼胝体干,MD值减小的区域为右侧顶下小叶缘上回(P0.001)。结论慢性SC的相关脑结构区发生改变,与认知、情绪、空间定位功能相关脑区的灰、白质结构发生改变,其中胼胝体对结构的重塑可能起着重要作用。联合使用VBM及DTI可显示慢性SCI后脑结构的重塑。
[Abstract]:Objective to investigate the changes of gray and white matter in the whole brain of patients with chronic spinal cord injury (sci) by using VBM and diffusion Zhang Liang imaging. Methods whole brain volume and DTI scanning were performed in 20 patients with chronic SCI and 30 healthy volunteers (control group). The changes of gray, white matter structure and integrity of fibrous bundles were analyzed. Results compared with the control group, the decrease of gray matter volume in the sci group was mainly in the left primary motor cortex (M1), the left premotor area (PMAA), the right anterior cingulate gyrus, the right straight gyrus, the left inferior frontal gyrus, the right infratemporal gyrus, the left middle occipital gyrus and the right anterior cuneate lobe (P0.001). The decrease of white matter volume was mainly in bilateral auxiliary motor area, bilateral pyramidal bundle walking area, and the decrease of left M1 and corpus callosum P0.001. FA value was mainly in the corpus callosum trunk. In the left anterior limb of the internal capsule and the left inferior parietal lobule, the decrease of MD value in the corpus callosum trunk was found in the right inferior parietal lobule superior gyrus (P0.001). Conclusion the changes of brain structure in chronic SC are associated with cognitive, emotional and spatial localization functions. Callosum may play an important role in the remodeling of the brain structure, among which the corpus callosum may play an important role in the remodeling of the brain structure. Combined use of VBM and DTI can demonstrate the remodeling of brain structure after chronic SCI.
【作者单位】：首都医科大学宣武医院放射科北京磁共振成像和脑信息学重点实验室;天津医科大学总医院放射科;
【基金】：国家自然科学基金(81271556) 北京市自然科学基金(7113155) 北京市教委科研计划(KM201210025013)
【分类号】：R445.2;R651.2

【参考文献】