缺血性脑白质病变DCE-MRI药代动力学模型选择

发布时间：2018-06-02 12:27

本文选题：血脑屏障 + 磁共振成像　；参考：《放射学实践》2017年11期

【摘要】：目的:探讨动态对比增强磁共振成像不同计算模型在缺血性脑白质病中的应用价值。方法:2016年4月-10月共搜集57例受试者,根据Fazekas评分分为两组:0~2分为对照组(共18例,男10例,女8例),3~6分为病例组(共39例,男17例,女22例)。所有研究对象进行DCE-MRI检查,通过两种不同的计算模型(Patlak模型、Extended Tofts双室模型)测量研究对象脑白质病变区域的容积转运常数(Ktrans),采用Mann-Whitney U检验比较两组Ktrans值的差异,并应用ROC曲线分析不同计算模型所得Ktrans值的敏感度及特异度。结果:Patlak模型计算所得两组的Ktrans值分别为0.20(0.05,0.31)×10~(-4) min~(-1),0.62(0.39,1.12)×10~(-4) min~(-1),Extended Tofts模型计算所得两组的Ktrans值的分别为4.00(1.80,5.99)×10~(-4) min~(-1)、7.20(4.60,13.20)×10~(-4) min~(-1),两种模型计算所得Ktrans值病例组均明显高于对照组,差异有统计学意义(P0.001)。Patlak模型所得Ktrans值的诊断效能较Extended Tofts模型所得Ktrans值诊断效能高,敏感度为74.36%,特异度94.44%。结论:应用DCE-MRI可以为缺血性脑白质病变发病机制提供重要参考,Patlak模型更适用于评价缺血性脑白质病。
[Abstract]:Objective: To explore the application value of different dynamic contrast enhanced MRI models in ischemic brain white matter disease. Methods: in April 2016, 57 subjects were collected and divided into two groups according to the Fazekas score: 0~2 was divided into control group (18 cases, 10 men, 8 women), and 3~6 was divided into cases group (39 cases, 17 men, 22 women). The volume transport constant (Ktrans) of the brain white matter area was measured by two different computing models (Patlak model, Extended Tofts double chamber model). The difference of Ktrans value between the two groups was compared with the Mann-Whitney U test, and the sensitivity and specificity of the Ktrans values obtained by the ROC curve analysis were analyzed by the ROC curve analysis. Results: the Ktrans values of the two groups calculated by the Patlak model were 0.20 (0.05,0.31) x 10~ (-4) min~ (-1) and 0.62 (0.39,1.12) * 10~ (-4) min~ (-1). The values of the two groups were 4, 7.20, and two, respectively. The difference was significantly higher than that of the control group. The difference was statistically significant (P0.001) the diagnostic efficiency of the Ktrans value of the.Patlak model was higher than the Ktrans value of the Extended Tofts model, the sensitivity was 74.36%, the specificity 94.44%. conclusion: the application of DCE-MRI to provide an important reference for the pathogenesis of ischemic brain white matter disease, Patlak model is more suitable. It is used to evaluate ischemic brain white matter disease.
【作者单位】：首都医科大学附属北京朝阳医院放射科;首都医科大学附属北京朝阳医院神经内科;
【基金】：国家自然科学基金(81271309)
【分类号】：R445.2;R742

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