肝细胞肝癌扩散加权成像ADC值与Ki-67的相关性研究

发布时间：2018-06-03 03:30

本文选题：肝细胞肝癌 + 扩散加权成像　；参考：《临床放射学杂志》2017年12期

【摘要】：目的探讨肝细胞肝癌表观扩散系数(ADC)值与Ki-67指数之间的关联性,更全面地了解肝癌的恶性程度、增殖活性。方法经手术病理证实的59例肝癌患者,术前在b值为600的DWI图像上测量ADC值,术后S-P免疫组织化学染色Ki-67,两者数据再通过Speaman行相关性分析。结果 59例肝癌患者分成低分化、中分化和高分化组。高分化组肝癌平均ADC值为(1.173±0.076)×10~(-3)mm~2/s,中分化组平均ADC值(1.036±0.079)×10~(-3)mm~2/s,低分化组平均ADC值为(0.824±0.145)×10~(-3)mm~2/s。高分化组Ki-67平均值为11.600%;中分化组平均值为29.808%;低分化组平均值为59.722%。通过Spearman等级相关系数分析得出肝癌Ki-67与ADC值呈负相关(r=-0.80492,P0.001)。结论肝癌ADC值与Ki-67指标呈负相关,能够在术前为了解肝癌生物学特性提供影像学依据,并为临床提供更好的治疗方案。
[Abstract]:Objective to investigate the correlation between the apparent diffusion coefficient (ADCC) and Ki-67 index of hepatocellular carcinoma (HCC) in order to understand the malignancy and proliferative activity of HCC. Methods ADC was measured on DWI images with b value 600 in 59 patients with liver cancer confirmed by operation and pathology. S-P immunohistochemical staining Ki-67 was performed after operation. The correlation of the two data was analyzed by Speaman. Results 59 patients with liver cancer were divided into low differentiation group, middle differentiation group and high differentiation group. The average ADC value of well-differentiated liver cancer was 1.173 卤0.076) 脳 10 ~ (-3) mm ~ (-2) / s, the average ADC value of moderately differentiated group was 1.036 卤0.079) 脳 10 ~ (-3) mm ~ (-1) / s, and the average ADC value of low differentiation group was 0.824 卤0.145) 脳 10 ~ (-3) mm ~ (2 / s). The average value of Ki-67 was 11.600 in the well-differentiated group, 29.808 in the middle differentiation group and 59.722 in the low-differentiated group. According to the analysis of Spearman grade correlation coefficient, the Ki-67 and ADC value of HCC were negatively correlated with ADC value (r = 0.80492, P 0.001). Conclusion the ADC value of HCC is negatively correlated with Ki-67 index, which can provide imaging basis for understanding biological characteristics of HCC before operation, and provide a better treatment scheme for clinic.
【作者单位】：内蒙古赤峰学院附属医院CT/MRI室;大连医科大学附属第二医院放射科;
【分类号】：R445.2;R735.7

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