肺癌CT能谱成像:定量分析及与TTF-1和EGFR表达水平的相关性

发布时间：2018-06-04 04:05

  本文选题：肺癌 + 体层摄影术　； 参考：《放射学实践》2017年08期

【摘要】：目的:探讨能谱CT成像相关参数在反映肺癌生物学特征中的作用。方法:搜集我院60例经病理证实的肺鳞癌和腺癌患者的病例资料,所有患者采用能谱模式行CT平扫和增强扫描,获得病灶的定量参数值,包括标准化碘浓度(NIC)、能谱曲线斜率(K)和钙含量。采用免疫组化法测量EGFR和TTF-1在癌细胞中的表达水平。结果:27例肺腺癌中EGFR表达阳性20例、阴性7例,阳性组和阴性组中NIC分别为0.27±0.16和0.15±0.10,K分别为2.04±0.17和1.79±0.25,两组间的差异均具有统计学意义(P0.05)。33例肺鳞癌中EGFR表达阳性19例、阴性14例,阳性组和阴性组中NICs分别为0.30±0.18和0.16±0.04,K分别为2.75±1.10和2.06±0.38,病灶内钙含量分别为6.57±0.67和4.73±1.56,两组间的差异均具有统计学意义(P0.05)。结论:能谱CT成像参数中标准化碘含量和曲线斜率(K)可反映肺癌病灶的血供情况及微血管密度,肺鳞癌中钙含量是反映肺鳞癌生长状态的参考指标。
[Abstract]:Objective: to investigate the role of spectral CT imaging parameters in reflecting the biological characteristics of lung cancer. Methods: the data of 60 cases of lung squamous cell carcinoma and adenocarcinoma confirmed by pathology in our hospital were collected. It includes standardized iodine concentration, energy spectrum curve slope K) and calcium content. The expression of EGFR and TTF-1 in cancer cells was measured by immunohistochemical method. Results in 27 cases of lung adenocarcinoma, 20 cases were positive for EGFR and 7 cases were negative. The NIC of positive group and negative group were 0.27 卤0.16 and 0.15 卤0.10K, 2.04 卤0.17 and 1.79 卤0.25, respectively. The difference between the two groups was statistically significant in 19 cases of positive EGFR expression and 14 cases of negative expression of EGFR in 33 cases of lung squamous cell carcinoma. In the positive group and the negative group, NICs was 0.30 卤0.18 and 0.16 卤0.04, K was 2.75 卤1.10 and 2.06 卤0.38, respectively. The calcium content in the lesion was 6.57 卤0.67 and 4.73 卤1.56, respectively. The difference between the two groups was statistically significant (P 0.05). Conclusion: the standardized iodine content and curve slope K in EDS CT imaging parameters can reflect the blood supply and microvessel density of lung cancer focus. Calcium content in lung squamous cell carcinoma is a reference index to reflect the growth state of lung squamous cell carcinoma.
【作者单位】： 湖北省襄阳市中心医院放射科(湖北文理学院附属医院);
【分类号】：R730.44;R734.2
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本文编号：1975822