急性大动脉粥样硬化性脑卒中患者颈动脉斑块超声造影定量指标与循环血白细胞的关系

发布时间：2018-06-06 01:44

本文选题：超声造影成像技术 + 动脉粥样硬化　；参考：《上海交通大学学报(医学版)》2017年12期

【摘要】：目的·探讨急性大动脉粥样硬化性脑卒中(LAAS)患者颈动脉斑块超声造影定量指标与循环血白细胞的相关性及其价值。方法·选择2016年6月—2017年6月于上海交通大学附属第一人民医院收治的LAAS患者62例(脑卒中组),选取同期对照组受试者48例。颈动脉优势斑块行超声造影,获取斑块时间-强度曲线(TIC)定量参数,即峰值强度(PTIC)和强度均值(MTIC);斑块时间-强度拟合曲线(FC)定量参数,即峰值(PFC)、锐度(SFC)和曲线下面积(AUCFC)。斑块定量参数的组间比较用两样本t检验,与循环血白细胞计数的相关性采用Pearson相关分析。结果·(1)脑卒中组患者总白细胞、中性粒细胞计数高于对照组,而淋巴细胞计数低于对照组(均P0.05)。(2)脑卒中组患者斑块超声造影定量参数PTIC、MTIC、PFC、SFC和AUCFC值均大于对照组(均P0.05)。(3)PTIC、MTIC和PFC与淋巴细胞数呈负相关(r分别为-0.291、-0.263和-0.270,均P0.05);SFC和AUCFC与中性粒细胞数呈正相关(r分别为0.261和0.298,均P0.05)。结论·颈动脉斑块的定量超声造影定量指标与循环血白细胞相关,其关联性有助于判断斑块的易损性。
[Abstract]:Objective to investigate the relationship between quantitative indices of carotid plaque and circulating white blood cells (WBC) in patients with acute atherosclerotic stroke. Methods from June 2016 to June 2017, 62 patients with LAAS were selected from the first people's Hospital affiliated to Shanghai Jiaotong University (stroke group) and the control group (48 subjects). Carotid artery dominant plaques were examined by contrast-enhanced echocardiography to obtain the quantitative parameters of time intensity curve (TIC), peak intensity (PTIC) and mean intensity (MTIC), and plaque time-intensity fitting curve (FCC), i.e. peak value PFC (PFC), acuity (SFC), and area under the curve (AUCFC). The correlation between the quantitative parameters of plaque and circulating white blood cell count was analyzed by Pearson correlation analysis. Results 1) the total leukocyte and neutrophil counts in stroke group were higher than those in control group. However, the lymphocyte count was lower than that in the control group (P0.050.263,0.270), and the quantitative parameters of PTICMTIC-PFCU and AUCFC in the stroke group were higher than those in the control group (P0.05A, P < 0.05). The negative correlation between the lymphocyte count and the number of lymphocytes was -0.291- 0.263 and -0.270, respectively, both P0.05SFC, AUCFC and neuter were significantly higher than those in the control group (P < 0.05), but the correlation between the lymphocyte count and the number of lymphocytes was negative (-0.291- 0.263) and (-0.270), respectively. The positive correlation of granulocyte number was 0.261 and 0.298, respectively (P 0.05). Conclusion quantitative contrast-enhanced echocardiography is associated with circulating white blood cells in carotid plaques, which is helpful to determine the vulnerability of carotid plaques.
【作者单位】：上海交通大学附属第一人民医院超声影像科;上海交通大学附属第一人民医院心超室;
【基金】：上海市科学技术委员会医学引导类科技项目(15411969100,16411969300) 上海市卫生和计划生育委员会基金(201440290,201640043) 促进市级医院临床技能与临床创新能力三年行动计划(16CR3105B) 上海交通大学医工交叉研究基金(YG2015MS28);上海交通大学医学院科技处技术转移推广项目(ZT201710,ZT201711)~~
【分类号】：R445.1;R743.3

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